Asgarirad Hossein, Chabra Aroona, Rahimnejad Mahnaz, Zaghi Hosseinzadeh Ahmad, Davoodi Ali, Azadbakht Mohammad
Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
World J Plast Surg. 2018 Jan;7(1):34-44.
Large numbers of population suffer from burn annually. The promising treatment of burn has not been identified yet. () in family is popular for its antiseptic activity. This prospective study was designed to compare the wound healing effects of gel (AG) with silver sulfadiazine (SSD).
This single blind clinical trial was performed on 40 patients with second and third degree burns. 20 patients treated with SSD and 20 other patients received . The percentage of the wound healing was evaluated with pain, irritation, edema, itching, erythema, purulent discharges and skin discoloration symptoms. Also, the patients' satisfaction and adverse drug reactions were determined.
The severity of pain (=0.03), inflammation (=0.02) and purulent secretions (=0.03) were significantly relieved in group. The healing time significantly reduced in second degree burns (=0.03) and third degree burns (=0.04) with treating by . No significant adverse drug reactions were detected with .
It seems that improves the different therapeutic aspects of burn injuries and could be considered as a new herbal remedy in wound healings.
每年有大量人群遭受烧伤。目前尚未确定有前景的烧伤治疗方法。（）在家庭中因其抗菌活性而广受欢迎。本前瞻性研究旨在比较（）凝胶（AG）与磺胺嘧啶银（SSD）对伤口愈合的影响。
本单盲临床试验对40例二度和三度烧伤患者进行。20例患者接受SSD治疗，另外20例患者接受（）治疗。通过疼痛、刺激、水肿、瘙痒、红斑、脓性分泌物和皮肤变色症状评估伤口愈合百分比。此外，还确定了患者的满意度和药物不良反应。
（）组患者的疼痛严重程度（=0.03）、炎症（=0.02）和脓性分泌物（=0.03）明显减轻。用（）治疗时，二度烧伤（=0.03）和三度烧伤（=0.04）的愈合时间显著缩短。使用（）未检测到明显的药物不良反应。
（）似乎改善了烧伤损伤的不同治疗方面，可被视为伤口愈合中的一种新的草药疗法。
