• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

从永兴岛采集的软珊瑚 sp. 中提取的萜类化合物。

Terpenoids from the Soft Coral sp. Collected in Yongxing Island.

机构信息

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Yushan Road 5, Qingdao 266003, China.

Laboratory of Marine Drugs and Biological Products, National Laboratory for Marine Science and Technology, Qingdao 266235, China.

出版信息

Mar Drugs. 2018 Apr 13;16(4):127. doi: 10.3390/md16040127.

DOI:10.3390/md16040127
PMID:29652789
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5923414/
Abstract

Three new sesquiterpenoids (sinuketal (), sinulins A and B ( and )) and two new cembranoids (sinulins C and D ( and )), as well as eight known sesquiterpenoids () and eight known cembranoids (), were isolated from the Xisha soft coral sp. Their structures were elucidated by extensive spectroscopic analysis. Compound possesses an unprecedented isopropyl-branched bicyclo [6.3.0] undecane carbon skeleton with unique endoperoxide moiety, and a plausible biosynthetic pathway of it was postulated. According to the reported biological properties of endoperoxide, the antimalarial, cytotoxic, antiviral, and target inhibitory activities of were tested. Compound showed mild in vitro antimalarial activity against 3D7, weak cytotoxic activities toward Jurkat, MDA-MB-231, and U2OS cell lines, inhibitory effects against influenza A viruses H1N1 and PR8, as well as mild target inhibitory activity against acetylcholinesterase. The other compounds were evaluated for cytotoxicities against HeLa, HCT-116, and A549 tumor cell lines and target inhibitory activities against protein tyrosine phosphatase 1B (PTP1B). Compound exhibited cytotoxicities against HeLa and HCT-116, and compounds , , and showed mild target inhibitory activities against PTP1B.

摘要

从西沙软珊瑚 sp. 中分离得到三个新的倍半萜（sinuketal ()，sinulins A 和 B ( 和 )）和两个新的柏木烷（sinulins C 和 D ( 和 )），以及八个已知的倍半萜 () 和八个已知的柏木烷 ()。通过广泛的光谱分析阐明了它们的结构。化合物 具有前所未有的异丙基支链双环 [6.3.0] 十一烷碳骨架和独特的内过氧化物部分，提出了其可能的生物合成途径。根据内过氧化物的报道生物活性，测试了 的抗疟、细胞毒性、抗病毒和靶标抑制活性。化合物 对 3D7 具有温和的体外抗疟活性，对 Jurkat、MDA-MB-231 和 U2OS 细胞系表现出较弱的细胞毒性，对流感 A 病毒 H1N1 和 PR8 具有抑制作用，以及对乙酰胆碱酯酶的温和靶标抑制活性。其他化合物被评估对 HeLa、HCT-116 和 A549 肿瘤细胞系的细胞毒性和对蛋白酪氨酸磷酸酶 1B（PTP1B）的靶标抑制活性。化合物 对 HeLa 和 HCT-116 表现出细胞毒性，化合物 、 、 和 对 PTP1B 表现出温和的靶标抑制活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5880/5923414/4e2308ba3bd9/marinedrugs-16-00127-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5880/5923414/346de9418f72/marinedrugs-16-00127-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5880/5923414/04b03cc0628d/marinedrugs-16-00127-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5880/5923414/a4a3b43402c1/marinedrugs-16-00127-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5880/5923414/c1fbde7c9a6e/marinedrugs-16-00127-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5880/5923414/2a1ddc9fde51/marinedrugs-16-00127-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5880/5923414/f40f9a908600/marinedrugs-16-00127-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5880/5923414/4e2308ba3bd9/marinedrugs-16-00127-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5880/5923414/346de9418f72/marinedrugs-16-00127-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5880/5923414/04b03cc0628d/marinedrugs-16-00127-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5880/5923414/a4a3b43402c1/marinedrugs-16-00127-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5880/5923414/c1fbde7c9a6e/marinedrugs-16-00127-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5880/5923414/2a1ddc9fde51/marinedrugs-16-00127-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5880/5923414/f40f9a908600/marinedrugs-16-00127-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5880/5923414/4e2308ba3bd9/marinedrugs-16-00127-g006.jpg

相似文献

1
Terpenoids from the Soft Coral sp. Collected in Yongxing Island.从永兴岛采集的软珊瑚 sp. 中提取的萜类化合物。
Mar Drugs. 2018 Apr 13;16(4):127. doi: 10.3390/md16040127.
2
Metabolites from the Paracel Islands Soft Coral cf. .来自西沙群岛软珊瑚的代谢产物
Mar Drugs. 2018 Dec 19;16(12):517. doi: 10.3390/md16120517.
3
Further New Diterpenoids as PTP1B Inhibitors from the Xisha Soft Coral Sinularia polydactyla.进一步从西沙软珊瑚 Sinularia polydactyla 中得到的作为 PTP1B 抑制剂的新二萜。
Mar Drugs. 2018 Mar 25;16(4):103. doi: 10.3390/md16040103.
4
Polyhydroxylated steroids from the South China Sea soft coral Sarcophyton sp. and their cytotoxic and antiviral activities.南海软珊瑚 Sarcophyton sp. 的多羟基甾醇及其细胞毒性和抗病毒活性。
Mar Drugs. 2013 Dec 2;11(12):4788-98. doi: 10.3390/md11124788.
5
Four new cembranoids from the Chinese soft coral Sinularia sp. and their anti-Aβ aggregation activities.中国软珊瑚 Sinularia sp. 中的四个新的海鞘素及其抗 Aβ 聚集活性。
Fitoterapia. 2019 Jul;136:104176. doi: 10.1016/j.fitote.2019.104176. Epub 2019 May 20.
6
Xeniaphyllane-Derived Terpenoids from Soft Coral Sinularia nanolobata.软珊瑚 Sinularia nanolobata 来源的 Xeniasphyllane 衍生萜类化合物。
Mar Drugs. 2018 Jan 24;16(2):40. doi: 10.3390/md16020040.
7
Antimicrobial Terpenoids from South China Sea Soft Coral sp.南海软珊瑚 sp. 的抗菌萜类化合物
Mar Drugs. 2021 May 22;19(6):294. doi: 10.3390/md19060294.
8
Uncommon terpenoids with anti-inflammatory activity from the Hainan soft coral Sinularia tumulosa.从海南软珊瑚 Sinularia tumulosa 中分离得到具有抗炎活性的罕见萜类化合物。
Bioorg Chem. 2020 Nov;104:104167. doi: 10.1016/j.bioorg.2020.104167. Epub 2020 Aug 25.
9
Eudesmane and aromadendrane sesquiterpenoids from the Vietnamese soft coral Sinularia erecta.来自越南软珊瑚直立肉芝软珊瑚的桉烷型和芳樟烷型倍半萜类化合物。
Nat Prod Res. 2018 Aug;32(15):1798-1802. doi: 10.1080/14786419.2017.1402326. Epub 2017 Nov 16.
10
Xeniaphyllane-derived terpenoids from the formosan soft coral Sinularia gibberosa.源自台湾软珊瑚瘤状棘软珊瑚的异叶烷型萜类化合物。
Chem Pharm Bull (Tokyo). 2007 Oct;55(10):1471-5. doi: 10.1248/cpb.55.1471.

引用本文的文献

1
The application and sustainable development of coral in traditional medicine and its chemical composition, pharmacology, toxicology, and clinical research.珊瑚在传统医学中的应用与可持续发展及其化学成分、药理学、毒理学和临床研究。
Front Pharmacol. 2024 Jan 3;14:1230608. doi: 10.3389/fphar.2023.1230608. eCollection 2023.
2
Natural Bioactive Compounds from Marine Invertebrates That Modulate Key Targets Implicated in the Onset of Type 2 Diabetes Mellitus (T2DM) and Its Complications.来自海洋无脊椎动物的天然生物活性化合物，其可调节与2型糖尿病（T2DM）发病及其并发症相关的关键靶点。
Pharmaceutics. 2023 Sep 14;15(9):2321. doi: 10.3390/pharmaceutics15092321.
3

本文引用的文献

1
Marine natural products.海洋天然产物。
Nat Prod Rep. 2018 Jan 16;35(1):8-53. doi: 10.1039/c7np00052a.
2
Immunomodulatory Polyketides from a Phoma-like Fungus Isolated from a Soft Coral.从一种软珊瑚中分离出的类茎点霉属真菌产生的免疫调节聚酮化合物。
J Nat Prod. 2017 Nov 22;80(11):2930-2940. doi: 10.1021/acs.jnatprod.7b00463. Epub 2017 Oct 19.
3
Artemisia annua mutant impaired in artemisinin synthesis demonstrates importance of nonenzymatic conversion in terpenoid metabolism.青蒿素合成受损的黄花蒿突变体证明了非酶促转化在萜类代谢中的重要性。
Enzyme Inhibitors from Gorgonians and Soft Corals.
海葵和软珊瑚中的酶抑制剂。
Mar Drugs. 2023 Jan 31;21(2):104. doi: 10.3390/md21020104.
4
Promising Antiparasitic Natural and Synthetic Products from Marine Invertebrates and Microorganisms.海洋无脊椎动物和微生物来源的有前途的抗寄生虫天然和合成产品。
Mar Drugs. 2023 Jan 25;21(2):84. doi: 10.3390/md21020084.
5
New Halogenated Compounds from Seaweed with Potential Inhibitory Activity against Malaria.海藻来源的新型含卤化合物及其抗疟活性
Molecules. 2022 Aug 31;27(17):5617. doi: 10.3390/molecules27175617.
6
Furanocembranoid from the Okinawan soft coral Sinularia sp.来自冲绳软珊瑚中华柳珊瑚属的呋喃二萜
Nat Prod Bioprospect. 2022 Mar 2;12(1):7. doi: 10.1007/s13659-022-00330-7.
7
Cytotoxic Compounds from Alcyoniidae: An Overview of the Last 30 Years.软柳珊瑚属的细胞毒性化合物：过去 30 年的综述。
Mar Drugs. 2022 Feb 11;20(2):134. doi: 10.3390/md20020134.
8
Chemical Diversity and Biological Activity of Secondary Metabolites from Soft Coral Genus since 2013.自 2013 年以来，软珊瑚属次级代谢产物的化学多样性和生物活性。
Mar Drugs. 2021 Jun 11;19(6):335. doi: 10.3390/md19060335.
9
Cembranoids of Soft Corals: Recent Updates and Their Biological Activities.软珊瑚的西松烷型二萜：近期进展及其生物活性
Nat Prod Bioprospect. 2021 Jun;11(3):243-306. doi: 10.1007/s13659-021-00303-2. Epub 2021 Apr 22.
10
Potentials of marine natural products against malaria, leishmaniasis, and trypanosomiasis parasites: a review of recent articles.海洋天然产物在抗疟疾、利什曼病和锥虫病寄生虫方面的潜力：对近期文章的综述。
Infect Dis Poverty. 2021 Jan 22;10(1):9. doi: 10.1186/s40249-021-00796-6.
Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):15150-15155. doi: 10.1073/pnas.1611567113. Epub 2016 Dec 7.
4
Hitorins A and B, Hexacyclic C Terpenoids from Chloranthus japonicus.来自日本金粟兰的六环C萜类化合物A和B。
Org Lett. 2016 Oct 21;18(20):5420-5423. doi: 10.1021/acs.orglett.6b02842. Epub 2016 Oct 10.
5
Casbane Diterpenes from Red Sea Coral Sinularia polydactyla.来自红海珊瑚多指软珊瑚的卡斯巴烷二萜类化合物。
Molecules. 2016 Mar 3;21(3):308. doi: 10.3390/molecules21030308.
6
Natural Endoperoxides as Drug Lead Compounds.作为药物先导化合物的天然内过氧化物。
Curr Med Chem. 2016;23(4):383-405. doi: 10.2174/0929867323666151127200949.
7
Cyclopentenone derivatives and polyhydroxylated steroids from the soft coral Sinularia acuta.来自尖刺软珊瑚的环戊烯酮衍生物和多羟基类固醇。
Chem Biodivers. 2015 Feb;12(2):273-83. doi: 10.1002/cbdv.201400044.
8
Polyhydroxylated steroids from the South China Sea soft coral Sarcophyton sp. and their cytotoxic and antiviral activities.南海软珊瑚 Sarcophyton sp. 的多羟基甾醇及其细胞毒性和抗病毒活性。
Mar Drugs. 2013 Dec 2;11(12):4788-98. doi: 10.3390/md11124788.
9
A new triterpenoid from Alisma orientale and their antibacterial effect.从泽泻中提取的一种新三萜及其抗菌作用。
Arch Pharm Res. 2012 Nov;35(11):1919-26. doi: 10.1007/s12272-012-1108-5. Epub 2012 Dec 4.
10
Sinularones A-I, new cyclopentenone and butenolide derivatives from a marine soft coral Sinularia sp. and their antifouling activity.辛纳酮 A-I，一种新型的环戊烯酮和丁烯内酯衍生物，来自海洋软珊瑚 Sinularia sp.，具有抗污活性。
Mar Drugs. 2012 Jun;10(6):1331-1344. doi: 10.3390/md10061331. Epub 2012 Jun 11.