Bhatia Garima, Goyal Neetu, Sharma Shailesh, Upadhyay Santosh Kumar, Singh Kashmir
Department of Biotechnology, BMS Block I, Panjab University, Sector 25, Chandigarh-160014, India.
National Agri-Food Biotechnology Institute, C-127, Industrial Area, S.A.S. Nagar, Phase 8, Mohali 160071, Punjab, India.
Noncoding RNA. 2017 Mar 24;3(2):16. doi: 10.3390/ncrna3020016.
Small non-coding RNAs have been extensively studied in plants over the last decade. In contrast, genome-wide identification of plant long non-coding RNAs (lncRNAs) has recently gained momentum. LncRNAs are now being recognized as important players in gene regulation, and their potent regulatory roles are being studied comprehensively in eukaryotes. LncRNAs were first reported in humans in 1992. Since then, research in animals, particularly in humans, has rapidly progressed, and a vast amount of data has been generated, collected, and organized using computational approaches. Additionally, numerous studies have been conducted to understand the roles of these long RNA species in several diseases. However, the status of lncRNA investigation in plants lags behind that in animals (especially humans). Efforts are being made in this direction using computational tools and high-throughput sequencing technologies, such as the lncRNA microarray technique, RNA-sequencing (RNA-seq), RNA capture sequencing, (RNA CaptureSeq), etc. Given the current scenario, significant amounts of data have been produced regarding plant lncRNAs, and this amount is likely to increase in the subsequent years. In this review we have documented brief information about lncRNAs and their status of research in plants, along with the plant-specific resources/databases for information retrieval on lncRNAs.
在过去十年中，小非编码RNA在植物中得到了广泛研究。相比之下，植物长非编码RNA（lncRNA）的全基因组鉴定最近才开始兴起。LncRNA现在被认为是基因调控中的重要参与者，其强大的调控作用正在真核生物中得到全面研究。LncRNA于1992年首次在人类中被报道。从那时起，动物尤其是人类的相关研究迅速发展，通过计算方法生成、收集并整理了大量数据。此外，人们还进行了大量研究以了解这些长RNA在多种疾病中的作用。然而，植物lncRNA的研究现状落后于动物（尤其是人类）。目前正使用计算工具和高通量测序技术，如lncRNA微阵列技术、RNA测序（RNA-seq）、RNA捕获测序（RNA CaptureSeq）等，朝着这个方向努力。鉴于当前的情况，已经产生了大量关于植物lncRNA的数据，并且在随后几年中这一数量可能会增加。在这篇综述中，我们记录了关于lncRNA及其在植物中的研究现状的简要信息，以及用于检索lncRNA信息的植物特异性资源/数据库。
