脑脊液免疫球蛋白作为基孔肯雅热脑炎的潜在生物标志物。
Cerebrospinal Fluid Immunoglobulins as Potential Biomarkers of Chikungunya Encephalitis.
出版信息
Emerg Infect Dis. 2018 May;24(5):939-941. doi: 10.3201/eid2405.171763.
Abstract
Chikungunya virus causes fever and severe polyarthritis or arthralgia and is associated with neurologic manifestations that are sometimes challenging to diagnose. We demonstrate intrathecal synthesis of chikungunya antibodies in a patient with a history of acute infection complicated by encephalitis. The specificity of the intracerebral immune response supports early chikungunya-associated encephalitis diagnosis.
摘要
基孔肯雅热病毒会引起发热和严重的多发性关节炎或关节痛，并伴有神经系统表现，有时难以诊断。我们在一名急性感染并发脑炎的患者中证明了基孔肯雅热抗体的鞘内合成。脑内免疫反应的特异性支持早期基孔肯雅热相关脑炎的诊断。
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