Peter Medawar Building for Pathogen Research and Translational Gastroenterology Unit, University of Oxford, Oxford, UK.
Immunol Rev. 2018 May;283(1):99-112. doi: 10.1111/imr.12653.
Memory inflation, as a term, has been used for 15 years now to describe the longitudinal development of stable, expanded CD8 T memory pools with a distinct phenotype and functional profile which emerge in specific infection and vaccine settings. These settings have in common the persistence of antigen, especially cytomegalovirus infection but also more recently adenoviral vector vaccination. However, in contrast to chronic infections which lead to "exhaustion" the repeated antigen encounters experienced by CD8 T cells lead to development of a robust T-cell population structure which maintains functionality and size. In this review, I will discuss how the ideas around this form of memory have evolved over time and some new models which can help explain how these populations are induced and sustained. These models are relevant to immunity against persistent viruses, to novel vaccine strategies and to concepts about aging.
记忆膨胀这个术语已经使用了 15 年，用于描述在特定感染和疫苗接种情况下出现的稳定、扩大的 CD8 T 记忆池的纵向发展，这些记忆池具有独特的表型和功能特征。这些情况的共同点是抗原的持续存在，特别是巨细胞病毒感染，但最近也包括腺病毒载体疫苗接种。然而，与导致“衰竭”的慢性感染相反，CD8 T 细胞反复接触抗原会导致形成一个强大的 T 细胞群体结构，维持其功能和大小。在这篇综述中，我将讨论围绕这种记忆形式的概念是如何随着时间的推移而演变的，以及一些新的模型可以帮助解释这些群体是如何被诱导和维持的。这些模型与针对持续性病毒的免疫、新型疫苗策略以及关于衰老的概念有关。
