无机多氢硫：化学、化学生物学与检测。
Inorganic hydrogen polysulfides: chemistry, chemical biology and detection.
机构信息
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules and College of Chemistry and Chemical Engineering, Hubei University, Wuhan, Hubei, China.
Department of Chemistry, Washington State University, Pullman, WA, USA.
出版信息
Br J Pharmacol. 2019 Feb;176(4):616-627. doi: 10.1111/bph.14330. Epub 2018 May 14.
Abstract
Recent studies suggest that inorganic hydrogen polysulfides (H S , n ≥ 2) play important regulatory roles in redox biology. Modulation of their cellular levels could have potential therapeutic value. This review article focuses on our current understanding of the biosynthesis, biofunctions, fundamental physical/chemical properties, detection methods and delivery techniques of H S . LINKED ARTICLES: This article is part of a themed section on Chemical Biology of Reactive Sulfur Species. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.4/issuetoc.
摘要
最近的研究表明，无机多氢硫代物（H₂S，n≥2）在氧化还原生物学中发挥着重要的调节作用。调节它们的细胞水平可能具有潜在的治疗价值。本文综述了 H₂S 的生物合成、生物功能、基本物理化学性质、检测方法和输送技术的研究进展。
相关文章
本文是本刊关于活性硫物种的化学生物学的专题的一部分。要查看该专题中的其他文章，请访问 http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.4/issuetoc.
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本文引用的文献
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A NIR fluorescent chemodosimeter for imaging endogenous hydrogen polysulfides via the CSE enzymatic pathway.一种用于通过CSE酶促途径对内源性多硫化氢进行成像的近红外荧光化学传感器。
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Metabolism of hydrogen sulfide (HS) and Production of Reactive Sulfur Species (RSS) by superoxide dismutase.硫化氢（HS）的代谢和超氧化物歧化酶产生的活性硫物种（RSS）。
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Toward Direct Protein S-Persulfidation: A Prodrug Approach That Directly Delivers Hydrogen Persulfide.直接蛋白质 S-过硫化：一种直接提供氢过硫化物的前药方法。
J Am Chem Soc. 2018 Jan 10;140(1):30-33. doi: 10.1021/jacs.7b09795. Epub 2017 Dec 8.
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The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY.2018 年 IUPHAR/BPS 药理学指南：更新和扩展，以包含新的免疫药理学指南。
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