Recent Development of Hydrogen Sulfide Releasing/Stimulating Reagents and Their Potential Applications in Cancer and Glycometabolic Disorders.

As an important endogenous gaseous signaling molecule, hydrogen sulfide (HS) exerts various effects in the body. A variety of pathological changes, such as cancer, glycometabolic disorders, and diabetes, are associated with altered endogenous levels of HS, especially decreased. Therefore, the supplement of HS is of great significance for the treatment of diseases containing the above pathological changes. At present, many efforts have been made to increase the levels of HS by administration of gaseous HS, simple inorganic sulfide salts, sophisticated synthetic slow-releasing controllable HS donors or materials, and using HS stimulating agents. In this article, we reviewed the recent development of HS releasing/stimulating reagents and their potential applications in two common pathological processes including cancer and glycometabolic disorders.