Ajiboye Basiru Olaitan, Adeleke Ojo Oluwafemi, Adeyonu Oluwatosin, Imiere Oluwatosin, Emmanuel Oyinloye Babatunji, Ogunmodede Oluwafemi
Department of Chemical Sciences, Biochemistry Programme, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.
Department of Chemical Sciences, Industrial Chemistry Programme, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.
Adv Pharm Bull. 2018 Mar;8(1):141-147. doi: 10.15171/apb.2018.017. Epub 2018 Mar 18.
Diabetes mellitus is one of the major endocrine disorders, characterized by impaired insulin action and deficiency. Traditionally, Artocarpus heterophyllus stem bark has been reputably used in the management of diabetes mellitus and its complications. The present study evaluates the ameliorative activity of ethanol extract of Artocarpus heterophyllus stem bark in alloxan-induced diabetic rats. Diabetes mellitus was induced by single intraperitoneal injection of 150 mg/kg body weight of alloxan and the animals were orally administered with 50, 100 and 150 mg/kg body weight ethanol extract of Artocarpus heterophyllus stem bark once daily for 21 days. At the end of the intervention, diabetic control rats showed significant (p<0.05) weight reduction, abnormal haematological parameters, high serum lipids (except high density lipoprotein) concentrations, increased creatinine, bilirubin and urea levels with decreased in albumin level when compared with non-diabetic control rats. All these alterations were reverted to normal after administered with different doses of ethanol extract of Artocarpus heterophyllus stem bark most especially at 150 mg/kg body weight which exhibited no significant (p>0.05) different with non-diabetic rats. The results suggest that ethanol extract of Artocarpus heterophyllus stem bark may be useful in ameliorating complications associated with diabetes mellitus patients.
糖尿病是主要的内分泌疾病之一，其特征为胰岛素作用受损和缺乏。传统上，波罗蜜树茎皮一直被广泛用于糖尿病及其并发症的治疗。本研究评估了波罗蜜树茎皮乙醇提取物对四氧嘧啶诱导的糖尿病大鼠的改善作用。通过腹腔注射150mg/kg体重的四氧嘧啶诱导糖尿病，然后给动物每日口服50、100和150mg/kg体重的波罗蜜树茎皮乙醇提取物，持续21天。干预结束时，与非糖尿病对照大鼠相比，糖尿病对照大鼠体重显著减轻（p<0.05），血液学参数异常，血清脂质（高密度脂蛋白除外）浓度升高，肌酐、胆红素和尿素水平升高，白蛋白水平降低。给予不同剂量的波罗蜜树茎皮乙醇提取物后，所有这些改变均恢复正常，尤其是150mg/kg体重剂量组，与非糖尿病大鼠相比无显著差异（p>0.05）。结果表明，波罗蜜树茎皮乙醇提取物可能有助于改善糖尿病患者的并发症。
