Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Hong Kong.
School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
J Diabetes Res. 2018 Feb 18;2018:8956509. doi: 10.1155/2018/8956509. eCollection 2018.
Visceral adiposity is associated with higher productions of C-reactive protein (CRP) and interleukin-6 (IL-6). Inflammation of obese adipose tissues could contribute to systemic metabolic dysregulation, especially thermogenic activity of white adipose tissues, namely, beige adipogenesis, characterized by altered irisin expression. Thus, we investigated the roles of inflammation and adipocyte beiging in Chinese centrally obese (CO) adults with metabolic syndrome (MetS).
This cross-sectional study was conducted on 54 CO and 58 non-CO subjects drawn from 1492 Chinese people with age and sex matched during November 2010 and August 2013. Twenty (37.0%) of the CO subjects fulfilled the IDF worldwide definition of MetS. Serum CRP, IL-6, and irisin levels were examined.
Higher CRP and IL-6, but lower irisin, levels were manifested in MetS versus non-MetS subjects with or without CO. Multiple linear regression identified high-density lipoprotein cholesterol level as the only independent risk factor for irisin level. Categorized by median of CRP and IL-6 levels, a lower irisin level was only observed in high CRP group.
Under the condition of central obesity, chronic inflammation and impaired beige adipogenesis are associated with MetS in Chinese adults.
内脏肥胖与 C 反应蛋白（CRP）和白细胞介素-6（IL-6）的产生增加有关。肥胖脂肪组织的炎症可能导致全身代谢失调，特别是白色脂肪组织的产热活性，即米色脂肪生成，其特征是鸢尾素表达改变。因此，我们研究了炎症和脂肪细胞米色形成在有代谢综合征（MetS）的中国中心性肥胖（CO）成年人中的作用。
这项横断面研究于 2010 年 11 月至 2013 年 8 月期间从 1492 名中国成年人中选取了 54 名 CO 和 58 名非 CO 受试者，这些受试者的年龄和性别与 CO 相匹配。20 名（37.0%）CO 受试者符合 IDF 全球代谢综合征定义。检测了血清 CRP、IL-6 和鸢尾素水平。
在有或没有 CO 的 MetS 与非 MetS 受试者中，CRP 和 IL-6 水平较高，而鸢尾素水平较低。多元线性回归确定高密度脂蛋白胆固醇水平是鸢尾素水平的唯一独立危险因素。按 CRP 和 IL-6 水平中位数分类，仅在 CRP 较高组中观察到鸢尾素水平较低。
在中心性肥胖的情况下，慢性炎症和米色脂肪生成受损与中国成年人的 MetS 有关。
