鸢尾素：代谢紊乱中的一种新型分子标志物及靶点。
Irisin: a new molecular marker and target in metabolic disorder.
作者信息
Chen Jia-qi, Huang Yue-ye, Gusdon Aaron M, Qu Shen
机构信息
Department of Endocrinology and Metabolism, Shanghai 10th People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
出版信息
Lipids Health Dis. 2015 Jan 14;14:2. doi: 10.1186/1476-511X-14-2.
Abstract
Irisin is a newly discovered exercise-mediated myokine which regulates energy metabolism and has been the subject of much recent research. Irisin plays an important role in metabolic diseases making it a potential new target to combat obesity and its associated disorders, such as T2DM. However, the results of several recent studies investigating the effects of irisin have been controversial. The present review will introduce the discovery of irisin, the role of irisin in metabolic disorders, possible mechanisms, and unanswered questions for future research.
摘要
鸢尾素是一种新发现的由运动介导的肌动蛋白，它调节能量代谢，并且是近期众多研究的主题。鸢尾素在代谢性疾病中发挥重要作用，使其成为对抗肥胖及其相关疾病（如2型糖尿病）的潜在新靶点。然而，最近几项研究鸢尾素作用的结果存在争议。本综述将介绍鸢尾素的发现、其在代谢紊乱中的作用、可能的机制以及未来研究中尚未解决的问题。
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本文引用的文献
1
Association between serum irisin levels and non-alcoholic fatty liver disease in health screen examinees.健康筛查受检者血清鸢尾素水平与非酒精性脂肪性肝病之间的关联。
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Circulating irisin, omentin-1, and lipoprotein subparticles in adults at higher cardiovascular risk.循环鸢尾素、网膜素-1 和心血管风险较高成年人的脂蛋白亚颗粒。
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Circulating irisin and glucose-dependent insulinotropic peptide are associated with the development of polycystic ovary syndrome.循环鸢尾素和葡萄糖依赖性胰岛素促分泌肽与多囊卵巢综合征的发展有关。
J Clin Endocrinol Metab. 2014 Dec;99(12):E2539-48. doi: 10.1210/jc.2014-1180.
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The association of new inflammatory markers with type 2 diabetes mellitus and macrovascular complications: a preliminary study.新型炎症标志物与2型糖尿病及大血管并发症的关联：一项初步研究。
Eur Rev Med Pharmacol Sci. 2014 Jun;18(11):1567-72.
5
Irisin levels are lower in young amenorrheic athletes compared with eumenorrheic athletes and non-athletes and are associated with bone density and strength estimates.与月经正常的运动员和非运动员相比，年轻闭经运动员的鸢尾素水平较低，且与骨密度和力量评估相关。
PLoS One. 2014 Jun 13;9(6):e100218. doi: 10.1371/journal.pone.0100218. eCollection 2014.
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Circulating irisin levels are positively associated with endothelium-dependent vasodilation in newly diagnosed type 2 diabetic patients without clinical angiopathy.在新诊断的无临床血管病变的2型糖尿病患者中，循环鸢尾素水平与内皮依赖性血管舒张呈正相关。
Atherosclerosis. 2014 Aug;235(2):328-33. doi: 10.1016/j.atherosclerosis.2014.04.036. Epub 2014 May 22.
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Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index.鸢尾素与肥胖程度、静息能量消耗和极身体质量指数条件下的日常活动的关系。
Int J Endocrinol. 2014;2014:857270. doi: 10.1155/2014/857270. Epub 2014 Apr 22.
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Serum irisin concentration in women with gestational diabetes.妊娠期糖尿病女性的血清鸢尾素浓度
Gynecol Endocrinol. 2014 Sep;30(9):636-9. doi: 10.3109/09513590.2014.920006. Epub 2014 May 22.
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Circulating irisin levels are not affected by coffee intake: a randomized controlled trial.循环鸢尾素水平不受咖啡摄入的影响：一项随机对照试验。
PLoS One. 2014 Apr 11;9(4):e94463. doi: 10.1371/journal.pone.0094463. eCollection 2014.
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Association of serum irisin with metabolic syndrome in obese Chinese adults.中国肥胖成年人血清鸢尾素与代谢综合征的关联
PLoS One. 2014 Apr 7;9(4):e94235. doi: 10.1371/journal.pone.0094235. eCollection 2014.
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