a Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation , University of Groningen, University Medical Center Groningen , Groningen , The Netherlands.
b Department of Internal and Vascular Medicine , Academic Medical Center , Amsterdam , The Netherlands.
Crit Rev Clin Lab Sci. 2018 Jun;55(4):283-293. doi: 10.1080/10408363.2018.1463507. Epub 2018 Apr 20.
Psychiatric disorders are often associated with metabolic comorbidities. However, the mechanisms through which metabolic and psychiatric disorders are connected remain unclear. Pre-clinical studies in rodents indicate that the bidirectional signaling between the intestine and the brain, the so-called microbiome-gut-brain axis, plays an important role in the regulation of both metabolism and behavior. The gut microbiome produces a vast number of metabolites that may be transported into the host and play a part in homeostatic control of metabolism as well as brain function. In addition to short chain fatty acids, many of these metabolites have been identified in recent years. To what extent both microbiota and their products control human metabolism and behavior is a subject of intense investigation. In this review, we will discuss the most recent findings concerning alterations in the gut microbiota as a possible pathophysiological factor for the co-occurrence of metabolic comorbidities in psychiatric disorders.
精神障碍常与代谢合并症相关。然而，代谢和精神障碍之间关联的机制尚不清楚。啮齿动物的临床前研究表明，肠和脑之间的双向信号传递，即所谓的微生物组-肠-脑轴，在调节代谢和行为方面起着重要作用。肠道微生物组产生大量的代谢物，这些代谢物可能被转运到宿主体内，并在代谢和大脑功能的稳态控制中发挥作用。除了短链脂肪酸外，近年来还发现了许多其他代谢物。微生物组及其产物在多大程度上控制着人类的新陈代谢和行为，这是一个正在深入研究的课题。在这篇综述中，我们将讨论肠道微生物组改变作为精神障碍中代谢合并症共病的可能病理生理因素的最新发现。
