自噬：治疗眼内新生血管形成的潜在靶点。
Autophagy: a potential target for the treatment of intraocular neovascularization.
作者信息
Zhu Xia-Ru, Du Jun-Hui
机构信息
Department of Ophthalmology, Xi'an Ninth Hospital Affiliated to Medical College of Xi'an Jiaotong University, Xi'an 710054, Shaanxi Province, China.
出版信息
Int J Ophthalmol. 2018 Apr 18;11(4):695-698. doi: 10.18240/ijo.2018.04.26. eCollection 2018.
Abstract
The formation of neovascularization is a common pathological feature of many ocular vascular diseases, and is an important cause of vision loss in patients. Neovascularization can cause retinal hemorrhage, vitreous hemorrhage, and other serious complications, leading to loss of vision. The treatment of intraocular neovascularization is the focus of ophthalmology research. In recent years, some studies have found that autophagy is closely related to vascular endothelial growth factor and the formation of neovascularization. Autophagy is expected to become a new target for the treatment of intraocular neovascularization. Therefore, this article reviews the research on autophagy and the formation of intraocular neovascularization.
摘要
新生血管形成是许多眼部血管疾病的常见病理特征，也是患者视力丧失的重要原因。新生血管可导致视网膜出血、玻璃体出血等严重并发症，进而导致视力丧失。眼内新生血管的治疗是眼科研究的重点。近年来，一些研究发现自噬与血管内皮生长因子及新生血管形成密切相关。自噬有望成为治疗眼内新生血管的新靶点。因此，本文综述了自噬与眼内新生血管形成的研究。
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