Harry S. Truman Memorial Veteran Hospital, Columbia, MO, United States; One-Health One-Medicine Vision Research Center, University of Missouri, Columbia, MO, United States; College of Veterinary Medicine, University of Missouri, Columbia, MO, United States.
GROW Research Laboratory, Narayana Nethralaya Foundation, Bangalore, India.
Ocul Surf. 2019 Apr;17(2):186-197. doi: 10.1016/j.jtos.2019.01.008. Epub 2019 Jan 25.
Autophagy is a well-conserved self-eating mechanism of cell survival during periods of nutrient deprivation, stress and injury. Autophagy is implicated in many pathophysiological conditions across all organ systems. The cornea is an avascular transparent tissue that is prone to damage by trauma, injury and infection. Following insult, the cornea undergoes a complex wound healing process, which is regulated by multiple factors including autophagy. The involvement of autophagy in keratoconus and HSV-1 infection has been demonstrated, underlining the importance of this mechanism in corneal disorders. However, the role of autophagy in corneal wound repair, fibrosis and angiogenesis is still unclear. Recently, we characterized the expression of autophagy-related genes in cornea and are studying their role in the modulation of corneal conditions including fibrosis and dystrophies. Preliminary results presented within this review article support further investigation of the dynamic modulation of autophagy-related genes in corneal health and disease. This article provides an overview of how autophagy modulates corneal function.
自噬是一种在营养缺乏、应激和损伤期间细胞存活的高度保守的自我吞噬机制。自噬与所有器官系统的许多病理生理状况有关。角膜是一种无血管的透明组织，容易受到创伤、损伤和感染的损害。损伤后，角膜经历一个复杂的伤口愈合过程，该过程受多种因素的调节，包括自噬。自噬在圆锥角膜和 HSV-1 感染中的作用已经得到证实，这突显了该机制在角膜疾病中的重要性。然而，自噬在角膜伤口修复、纤维化和血管生成中的作用尚不清楚。最近，我们描述了自噬相关基因在角膜中的表达，并正在研究它们在调节包括纤维化和营养不良在内的角膜状况中的作用。本文中的初步结果支持进一步研究自噬相关基因在角膜健康和疾病中的动态调节。本文概述了自噬如何调节角膜功能。
