Fu Zhen-Na, Wang Ting, Bai Ming, Miao Ming-San
Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China.
Zhongguo Zhong Yao Za Zhi. 2018 Mar;43(6):1289-1291. doi: 10.19540/j.cnki.cjcmm.20180104.001.
This paper aimed to analyze the existing acne animal model based on the characteristics of acne clinical symptoms between Chinese and western medicine, in order to provide reference for the establishment of the rational acne animal model. Relevant literatures at home and abroad in recent years were reviewed to summarize the research progress of diagnostic criteria and drug treatment of acne with Chinese and western medicine, and analyze the existing acne animal model. The animal acne models were pathological models, and mainly reflected the clinical indicators of western medicine. Their evaluation was based on western medicine standard, with the standard of Chinese medicine for reference. More improved ideas and methods to establish acne animal models based on clinical study were put forward, so as to establish the reasonable quantitative standard for acne animal model. Furthermore, the animal model based on the combination of disease and syndrome was formed to provide a reliable experimental method for further study of acne. Rational acne animal model shall be selected according to the pathogenesis of acne, in order to improve the consistency between animal model and clinical symptoms, and lay a foundation for further study of acne.
本文旨在基于中西医痤疮临床症状特点分析现有的痤疮动物模型，为合理的痤疮动物模型建立提供参考。回顾近年来国内外相关文献，总结中西医对痤疮诊断标准及药物治疗的研究进展，并分析现有的痤疮动物模型。动物痤疮模型多为病理模型，主要反映西医临床指标，其评价以西医标准为主，参考中医标准。提出更多基于临床研究建立痤疮动物模型的改进思路和方法，以建立合理的痤疮动物模型量化标准。进而形成病证结合的动物模型，为痤疮的深入研究提供可靠的实验方法。应根据痤疮发病机制选择合理的痤疮动物模型，以提高动物模型与临床症状的一致性，为痤疮的进一步研究奠定基础。
