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去卵巢小鼠中染料木黄酮代谢物的营养动力学研究。

Nutrikinetic study of genistein metabolites in ovariectomized mice.

作者信息

Lee Da-Hye, Kim Min Jung, Song Eun-Ji, Kim Jin Hee, Ahn Jiyun, Nam Young-Do, Jang Young-Jin, Ha Tae-Youl, Jung Chang Hwa

机构信息

Research Group of Metabolic Mechanism, Korea Food Research Institute, Seongnam, Republic of Korea.

Department of Food Biotechnology, Korea University of Science and Technology, Seongnam, Republic of Korea.

出版信息

PLoS One. 2017 Oct 23;12(10):e0186320. doi: 10.1371/journal.pone.0186320. eCollection 2017.

DOI:10.1371/journal.pone.0186320
PMID:29059247
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5653299/
Abstract

This study was designed to evaluate the effect of ovariectomy on nutrikinetics of genistein metabolites. To characterize the time-dependent changes in genistein metabolite concentrations, we identified 13 genistein metabolites using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry. The nutrikinetics of the individual metabolites at different time points were analyzed. Nutrikinetic analysis showed that genistein, genistein 4'-glucuronide, genistein 7-glucuronide, 3-hydroxygenistein, and hippuric acid showed relatively high bioavailability in the sham group compared to that in the ovariectomy group, suggesting that ovariectomy likely results in lower genistein bioavailability. These results may be related to alteration of gut microbiota by ovariectomy. The relative abundance of species of the Parabacteroides, Dorea, and Butyricimonas genera, and Desulfovibrionaceae_unclassified, Lachnospiraceae_unclassified, and Rikenellaceae_unclassified families increased in the ovariectomy group while the relative abundance of 523_7_unclassified and Y52_unclassified_unclassified increased in the sham group. These results suggest that gut microbiota alteration by ovariectomy may affect genistein bioavailability.

摘要

本研究旨在评估卵巢切除术对染料木黄酮代谢产物营养动力学的影响。为了表征染料木黄酮代谢产物浓度随时间的变化，我们使用超高效液相色谱-四极杆飞行时间质谱法鉴定了13种染料木黄酮代谢产物。分析了不同时间点各个代谢产物的营养动力学。营养动力学分析表明，与卵巢切除组相比，假手术组中的染料木黄酮、染料木黄酮4'-葡萄糖醛酸苷、染料木黄酮7-葡萄糖醛酸苷、3-羟基染料木黄酮和马尿酸显示出相对较高的生物利用度，这表明卵巢切除术可能导致染料木黄酮生物利用度降低。这些结果可能与卵巢切除术引起的肠道微生物群改变有关。卵巢切除组中副拟杆菌属、多雷亚菌属和丁酸单胞菌属以及脱硫弧菌科未分类、毛螺菌科未分类和理研菌科未分类家族的物种相对丰度增加，而假手术组中523_7未分类和Y52未分类未分类的相对丰度增加。这些结果表明，卵巢切除术引起的肠道微生物群改变可能会影响染料木黄酮的生物利用度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b2/5653299/4d5d2890fc12/pone.0186320.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b2/5653299/3f4001b72e33/pone.0186320.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b2/5653299/07d05698b3ab/pone.0186320.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b2/5653299/4d5d2890fc12/pone.0186320.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b2/5653299/3f4001b72e33/pone.0186320.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b2/5653299/07d05698b3ab/pone.0186320.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b2/5653299/4d5d2890fc12/pone.0186320.g003.jpg

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