Al-Koshab May, Ali-Saeed Rola, Alabsi Aied Mohammed, Abdelwahab Siddig Ibrahim, Azzani Meram, Ismail Muhamad Fareez, Al-Garadi Maged A, Subramaniyan Vetriselvan
Department of Oral & Craniofacial Sciences, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.
Department of Preclinical Sciences, Faculty of Dentistry, MAHSA University, Selangor, Malaysia.
Asian Pac J Cancer Prev. 2025 Apr 1;26(4):1269-1275. doi: 10.31557/APJCP.2025.26.4.1269.
The use of natural products has been gaining interest, notably, in the area of cancer therapy. In this study, we determined the chemotherapeutic activity of Tualang Honey (TH) Malaysian wild local honey, on an animal model induced for oral cancer using 4NQO.
A total of 28 male Sprague-Dawley (SD) rats were randomized into four groups (n=7 per group) as non-treated, treated (1000 mg/kg) 1000, treated 2000 mg/kg and control group. All groups' rats received 4NQO, followed by 10 weeks administration of TH at 1000 and 2000 mg/kg, respectively, for the treated groups. All rats from all experiments were sacrificed to evaluate the incidence of oral neoplasms with histopathological changes and histological evaluation of oral cancer metastasis.
TH significantly reduced the incidence of SCC from 100% to 28.6 % in the TH high dose group of 2000 mg/kg. furthermore, TH has the ability to inhibit the metastasis of oral cancer to adjacent organs.
TH inhibited the proliferation of the cancer cells in an animal model of oral squamous cell carcinoma and therefore, has the potential to be developed as a chemotherapeutic agent.
天然产物的应用越来越受到关注，尤其是在癌症治疗领域。在本研究中，我们测定了马来西亚当地野生蜂蜜——蜂兰蜂蜜（TH）对使用4NQO诱导的口腔癌动物模型的化疗活性。
将总共28只雄性Sprague-Dawley（SD）大鼠随机分为四组（每组n = 7），即未治疗组、治疗组（1000 mg/kg）、治疗组（2000 mg/kg）和对照组。所有组的大鼠均接受4NQO处理，随后治疗组分别以1000 mg/kg和2000 mg/kg的剂量给予TH，持续10周。处死所有实验中的大鼠，以评估口腔肿瘤的发生率、组织病理学变化以及口腔癌转移的组织学评估。
在2000 mg/kg的TH高剂量组中，TH显著将鳞状细胞癌的发生率从100%降低至28.6%。此外，TH具有抑制口腔癌向邻近器官转移的能力。
TH在口腔鳞状细胞癌动物模型中抑制了癌细胞的增殖，因此，有潜力被开发为一种化疗药物。
