Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; Centre for Natural Products Research and Drug Discovery (CENAR), University of Malaya, 50603 Kuala Lumpur, Malaysia.
Pharmacol Res. 2018 Jun;132:119-129. doi: 10.1016/j.phrs.2018.04.013. Epub 2018 Apr 21.
Endoplasmic reticulum (ER) is the main organelle for the synthesis, folding, and processing of secretory and transmembrane proteins. Pathological stimuli including hypoxia, ischaemia, inflammation and oxidative stress interrupt the homeostatic function of ER, leading to accumulation of unfolded proteins, a condition referred to as ER stress. ER stress triggers a complex signalling network referred as the unfolded protein response (UPR). Extensive studies have demonstrated that ER stress plays an important role in the pathogenesis of various cardiovascular diseases such as heart failure, ischemic heart disease and atherosclerosis. The importance of natural products in modern medicine are well recognized and continues to be of interests as a source of novel lead compounds. Natural products targeting components of UPR and reducing ER stress offers an innovative strategic approach to treat cardiovascular diseases. In this review, we discussed several therapeutic interventions using natural products with potential cardiovascular protective properties targeting ER stress signalling pathways.
内质网（ER）是合成、折叠和加工分泌蛋白和跨膜蛋白的主要细胞器。包括缺氧、缺血、炎症和氧化应激在内的病理刺激中断了内质网的稳态功能，导致未折叠蛋白的积累，这种情况被称为内质网应激。内质网应激触发了一个被称为未折叠蛋白反应（UPR）的复杂信号网络。大量研究表明，内质网应激在心力衰竭、缺血性心脏病和动脉粥样硬化等各种心血管疾病的发病机制中起着重要作用。天然产物在现代医学中的重要性是公认的，并且作为新型先导化合物的来源仍然具有吸引力。针对 UPR 成分和减少内质网应激的天然产物为治疗心血管疾病提供了一种创新的战略方法。在这篇综述中，我们讨论了几种使用天然产物的治疗干预措施，这些天然产物具有针对内质网应激信号通路的潜在心血管保护特性。
