Adoba Prince, Ephraim Richard K D, Kontor Kate Adomakowaah, Bentsil Joseph-Josiah, Adu Patrick, Anderson Maxwell, Sakyi Samuel Asamoah, Nsiah Paul
Department of Molecular Medicine, School of Medical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Department of Medical Laboratory Science, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.
Int J Pediatr. 2018 Mar 1;2018:3901505. doi: 10.1155/2018/3901505. eCollection 2018.
Neonatal jaundice (NNJ) is a major cause of hospital admission during the neonatal period and is associated with significant mortality. This case-control study with cross-sectional design sought to identify the possible factors associated with neonatal jaundice and assess maternal knowledge level of this condition.
One hundred and fifty (150) neonates comprising 100 with clinically evident jaundice and 50 without jaundice were conveniently recruited from the Trauma and Specialist Hospital in the Effutu Municipality. Blood samples were collected for the determination of serum bilirubin, glucose-6-phosphate dehydrogenase (G6PD), status and blood group (ABO and Rhesus). Well-structured questionnaire was used to collect maternal and neonate sociodemographic and clinical history.
Majority (54%) of neonates developed jaundice within 1-3 days after birth with 10% having it at birth. Duration of labour and neonatal birth weight were associated with neonatal jaundice ( < 0.05). G6PD abnormality was found in 11 (12%) of the neonates with jaundice and ABO incompatibility was present in 18%. Neonates delivered by mothers with formal occupation and those who had prolonged duration of labour were significantly more likely to have neonatal jaundice (OR = 4.174, = 0.003; OR = 2.389, = 0.025, resp.). Neonates with low birth weight were also more likely to develop neonatal jaundice (OR = 2.347, = 0.044). Only 17.3% of mothers had heard of neonatal jaundice. School was the major source of information on neonatal jaundice (34.6%). Majority of participants (mothers) did not know that NNJ can cause damage to other organs in the body (90%).
Low neonatal birth weight and prolonged duration of labour are associated with neonatal jaundice. Mothers had inadequate knowledge of neonatal jaundice and its causes.
新生儿黄疸(NNJ)是新生儿期住院的主要原因,且与显著的死亡率相关。这项采用横断面设计的病例对照研究旨在确定与新生儿黄疸相关的可能因素,并评估母亲对这种疾病的认知水平。
从埃富图市创伤专科医院方便地招募了150名新生儿,其中100名有临床明显黄疸,50名无黄疸。采集血样以测定血清胆红素、葡萄糖-6-磷酸脱氢酶(G6PD)状态和血型(ABO和恒河猴血型)。使用结构良好的问卷收集母亲和新生儿的社会人口统计学及临床病史。
大多数(54%)新生儿在出生后1至3天出现黄疸,10%在出生时即有黄疸。产程和新生儿出生体重与新生儿黄疸相关(<0.05)。在有黄疸的新生儿中,11名(12%)发现G6PD异常,18%存在ABO血型不合。母亲有正式职业分娩的新生儿以及产程延长的新生儿患新生儿黄疸的可能性显著更高(OR = 4.174,= 0.003;OR = 2.389,= 0.025)。低出生体重的新生儿也更易患新生儿黄疸(OR = 2.347,= 0.044)。只有17.3%的母亲听说过新生儿黄疸。学校是关于新生儿黄疸的主要信息来源(34.6%)。大多数参与者(母亲)不知道新生儿黄疸会对身体其他器官造成损害(90%)。
低新生儿出生体重和产程延长与新生儿黄疸相关。母亲对新生儿黄疸及其病因的了解不足。