Sousa Wendel C DE, T S Paz Andressa, Rocha Jamira D, Conceição Edemilson C DA, Almeida Luciane M DE, Chen Lee C, Borges Leonardo L, Bailão Elisa F L C
Universidade Estadual de Goiás, Câmpus Iporá, Av. R2, Qd.01, Jardim Novo Horizonte II, 76200-000 Iporá, GO, Brazil.
Laboratório de Pesquisa, Desenvolvimento & Inovação de Bioprodutos, Faculdade de Farmácia, Universidade Federal de Goiás, Rua 240, Setor Leste Universitário, 74605-170 Goiânia, GO, Brazil.
An Acad Bras Cienc. 2018 Apr-Jun;90(2):1565-1577. doi: 10.1590/0001-3765201720170714. Epub 2018 Apr 23.
Costus spiralis is a Brazilian native plant used in popular medicine, but the safety of this therapeutic use needs investigation. So, the aim of this study was to evaluate the cytogenotoxic and antigenotoxic effects of C. spiralis leaves or stems aqueous extracts on Allium cepa root cells. Moreover, a phytochemical screening and an antioxidant and antifungal activities evaluation were performed. C. spiralis aqueous extracts presented cytotoxicity, but no mutagenicity was observed. When the antigenotoxicity was evaluated, C. spiralis leaves aqueous extract presented preventive and modulatory effects on A. cepa root cells, reducing the sodium azide cytogenotoxic effects. In contrast, C. spiralis stems aqueous extract enhanced the sodium azide cytogenotoxicity in some conditions. The phytochemical screening revealed the presence of phenolic compounds in C. spiralis. When total phenolic content was determined, the leaves presented 73% more phenolic content than stems. Corroborating this data, C. spiralis leaves antioxidant potential was 30% higher than C. spiralis stems. However, these extracts did not present antifungal activity against Candida spp. In conclusion, empirical utilization of C. spiralis aqueous extracts should be avoided. Moreover, the cytotoxic effect of C. spiralis leaves and stems can play an important role in anticancer therapy and must be deeply studied.
螺旋闭鞘姜是一种原产于巴西的植物，用于民间医学，但这种治疗用途的安全性需要研究。因此，本研究的目的是评估螺旋闭鞘姜叶或茎水提取物对洋葱根尖细胞的细胞遗传毒性和抗遗传毒性作用。此外，还进行了植物化学筛选以及抗氧化和抗真菌活性评估。螺旋闭鞘姜水提取物具有细胞毒性，但未观察到致突变性。在评估抗遗传毒性时，螺旋闭鞘姜叶水提取物对洋葱根尖细胞具有预防和调节作用，降低了叠氮化钠的细胞遗传毒性作用。相比之下，螺旋闭鞘姜茎水提取物在某些条件下增强了叠氮化钠的细胞遗传毒性。植物化学筛选显示螺旋闭鞘姜中存在酚类化合物。在测定总酚含量时，叶中的酚含量比茎高73%。与此数据相符的是，螺旋闭鞘姜叶的抗氧化潜力比茎高30%。然而，这些提取物对念珠菌属没有抗真菌活性。总之，应避免经验性使用螺旋闭鞘姜水提取物。此外，螺旋闭鞘姜叶和茎的细胞毒性作用在抗癌治疗中可能发挥重要作用，必须深入研究。
