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脓毒症血容量不足管理专家声明。

Expert statement for the management of hypovolemia in sepsis.

机构信息

Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Department Anaesthesia and Intensive Care Units, IRCCS Istituto Clinico Humanitas, Humanitas University, Milan, Italy.

出版信息

Intensive Care Med. 2018 Jun;44(6):791-798. doi: 10.1007/s00134-018-5177-x. Epub 2018 Apr 25.

DOI:10.1007/s00134-018-5177-x
PMID:29696295
Abstract

Hypovolemia is frequent in patients with sepsis and may contribute to worse outcome. The management of these patients is impeded by the low quality of the evidence for many of the specific components of the care. In this paper, we discuss recent advances and controversies in this field and give expert statements for the management of hypovolemia in patients with sepsis including triggers and targets for fluid therapy and volumes and types of fluid to be given. Finally, we point to unanswered questions and suggest a roadmap for future research.

摘要

低血容量血症在脓毒症患者中很常见,可能导致更差的预后。由于许多特定护理成分的证据质量较低,这些患者的管理受到阻碍。在本文中,我们讨论了该领域的最新进展和争议,并就脓毒症患者低血容量血症的管理提出了专家意见,包括液体治疗的触发因素和目标以及要给予的液体量和类型。最后,我们指出了未解决的问题,并为未来的研究提出了路线图。

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N Engl J Med. 2018 Mar 1;378(9):819-828. doi: 10.1056/NEJMoa1711586. Epub 2018 Feb 27.
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Balanced Crystalloids versus Saline in Critically Ill Adults.重症成年患者中平衡晶体液与生理盐水的比较
识别老年脓毒症患者心肌损伤的危险因素。
Med Sci Monit. 2025 May 18;31:e947840. doi: 10.12659/MSM.947840.
4
Early initiated noradrenaline versus fluid therapy for hypotension and shock in the emergency department (VASOSHOCK): a protocol for a pragmatic, multi-center, superiority, randomized controlled trial.急诊科早期应用去甲肾上腺素与液体疗法治疗低血压和休克(VASOSHOCK):一项实用、多中心、优效性、随机对照试验方案
Scand J Trauma Resusc Emerg Med. 2025 Apr 7;33(1):59. doi: 10.1186/s13049-025-01369-4.
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Front Med (Lausanne). 2024 Nov 27;11:1490462. doi: 10.3389/fmed.2024.1490462. eCollection 2024.
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