Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Dermatology, Chang Gung Memorial Hospital Linkou and Taipei Branch, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island; Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island.
J Am Acad Dermatol. 2018 Aug;79(2):252-257.e6. doi: 10.1016/j.jaad.2018.04.036. Epub 2018 Apr 24.
Red and processed meat consumption has been associated with increased risk for several cancers, but the association with cutaneous melanoma risk has been inconclusive.
To investigate the association between red and processed meat intake and melanoma risk.
Dietary information was assessed by using food frequency questionnaires in 2 prospective cohorts: 75,263 women from the Nurses' Health Study (1984-2010) and 48,523 men from the Health Professionals Follow-up Study (1986-2010). Melanoma cases were confirmed by reviewing pathology records. Pooled multivariable hazard ratios and 95% confidence intervals were estimated by using Cox proportional hazards models.
A total of 679 female and 639 male melanoma cases were documented during follow-up. Red and processed meat intake was inversely associated with melanoma risk (P = .002 for trend); the pooled hazard ratios (95% confidence intervals) of the 2 cohorts were 1.00 (reference), 1.00 (0.87-1.14), 0.98 (0.86-1.13), 0.89 (0.77-1.02), and 0.81 (0.70-0.95) for increasing quintiles of intake.
Findings might have limited generalizability, considering that the cohorts were limited to white health professionals.
Red and processed meat intake was inversely associated with melanoma risk in these 2 cohorts.
红色肉类和加工肉类的摄入与多种癌症的风险增加有关，但与皮肤黑色素瘤风险的关联尚无定论。
调查红色和加工肉类摄入与黑色素瘤风险之间的关系。
通过使用食物频率问卷，在 2 项前瞻性队列研究中评估膳食信息：75263 名女性来自护士健康研究（1984-2010 年），48523 名男性来自健康专业人员随访研究（1986-2010 年）。通过审查病理记录来确认黑色素瘤病例。使用 Cox 比例风险模型估计多变量风险比和 95%置信区间。
在随访期间共记录了 679 例女性和 639 例男性黑色素瘤病例。红色和加工肉类的摄入与黑色素瘤风险呈负相关（趋势 P=0.002）；两个队列的合并风险比（95%置信区间）分别为 1.00（参考）、1.00（0.87-1.14）、0.98（0.86-1.13）、0.89（0.77-1.02）和 0.81（0.70-0.95），摄入量逐渐增加的五分位数。
考虑到队列仅限于白人健康专业人员，研究结果可能具有有限的普遍性。
在这两个队列中，红色和加工肉类的摄入与黑色素瘤风险呈负相关。
