正在接受不孕症治疗的患者宫颈黏液中乳铁蛋白和白细胞介素-6的浓度。
Concentration of lactoferrin and interleukin-6 in cervical mucus from patients being treated for infertility.
作者信息
Mitsukawa Kaori, Otsuki Katsufumi, Yanaihara Atsushi, Sawada Maki, Iwasaki Shinji, Okai Takashi
机构信息
Department of Obstetrics and Gynecology, Showa University school of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, Japan.
出版信息
Reprod Med Biol. 2006 May 19;5(2):105-109. doi: 10.1007/BF03016146. eCollection 2006 Jun.
The concentrations of the iron-binding protein lactoferrin (LF) and interleukin-6 (IL-6) were measured in the cervical mucus of patients being treated for infertility throughout the menstrual cycle. A total of 251 cervical mucus samples were obtained from the patients throughout the menstrual cycle. One hundred and fifty samples were from primary infertility patients with unexplained infertility and 101 samples were from secondary infertility patients as a control. The concentrations of LF and IL-6 were measured by enzyme immunoassays. The standard curve of LF concentrations ranged from 1.6 to 50 ng/mL. The mean LF and IL-6 concentrations in the cervical mucus of primary infertility patients were higher than that of the control patients (= 0.04, = 0.032, respectively) The LF and IL-6 concentrations were highly correlated ( < 0.0001). Elevated levels of IL-6 and LF in the cervical mucus were obtained from primary infertility patients. We speculate that LF might also be one of the causes of infertility and might play an important role in reproductive processes in the cervix. (Reprod Med Biol 2006; : 105-109).
在整个月经周期中，对接受不孕症治疗的患者宫颈黏液中的铁结合蛋白乳铁蛋白（LF）和白细胞介素-6（IL-6）浓度进行了测量。在整个月经周期中，共从患者处获取了251份宫颈黏液样本。其中150份样本来自不明原因原发性不孕症患者，101份样本来自继发性不孕症患者作为对照。LF和IL-6的浓度通过酶免疫测定法进行测量。LF浓度的标准曲线范围为1.6至50 ng/mL。原发性不孕症患者宫颈黏液中LF和IL-6的平均浓度高于对照患者（分别为= 0.04，= 0.032）。LF和IL-6浓度高度相关（< 0.0001）。原发性不孕症患者宫颈黏液中IL-6和LF水平升高。我们推测LF可能也是不孕症的原因之一，并且可能在宫颈的生殖过程中起重要作用。（《生殖医学与生物学》2006年；：105 - 109）
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