Renke Maria B, Marcinkowska Anna B, Kujach Sylwester, Winklewski Paweł J
Functional Near Infrared Spectroscopy Lab, Department of Human Physiology, Medical University of Gdańsk, Gdańsk, Poland.
Department of Electronics, Telecommunication and Informatics, Gdańsk University of Technology, Gdańsk, Poland.
Front Aging Neurosci. 2022 Feb 14;14:803332. doi: 10.3389/fnagi.2022.803332. eCollection 2022.
Brain perfusion declines with aging. Physical exercise represents a low-cost accessible form of intervention to increase cerebral blood flow; however, it remains unclear if exercise-induced amelioration of brain perfusion has any impact on cognition. We aimed to provide a state-of-the art review on this subject. A comprehensive search of the PubMed (MEDLINE) database was performed. On the basis of the inclusion and exclusion criteria, 14 studies were included in the analysis. Eleven of the studies conducted well-controlled exercise programs that lasted 12-19 weeks for 10-40 participants and two studies were conducted in much larger groups of subjects for more than 5 years, but the exercise loads were indirectly measured, and three of them were focused on acute exercise. Literature review does not show a direct link between exercise-induced augmentation of brain perfusion and better cognitive functioning. However, in none of the reviewed studies was such an association the primary study endpoint. Carefully designed clinical studies with focus on cognitive and perfusion variables are needed to provide a response to the question whether exercise-induced cerebral perfusion augmentation is of clinical importance.
脑灌注随衰老而下降。体育锻炼是一种低成本且易于实施的增加脑血流量的干预方式；然而，运动诱导的脑灌注改善是否对认知有任何影响仍不清楚。我们旨在对该主题进行最新综述。对PubMed（MEDLINE）数据库进行了全面检索。根据纳入和排除标准，14项研究被纳入分析。其中11项研究实施了精心控制的运动计划，持续12 - 19周，参与者为10 - 40人，另外两项研究在更大规模的受试者群体中进行了超过5年，但运动负荷是间接测量的，且其中三项研究聚焦于急性运动。文献综述未显示运动诱导的脑灌注增加与更好的认知功能之间存在直接联系。然而，在所综述的研究中，均未将这种关联作为主要研究终点。需要精心设计关注认知和灌注变量的临床研究，以回答运动诱导的脑灌注增加是否具有临床重要性这一问题。
