School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China; Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China; Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Vaccine. 2018 May 31;36(23):3208-3220. doi: 10.1016/j.vaccine.2018.04.062. Epub 2018 Apr 26.
Chronic inflammatory autoimmune diseases leading to target tissue destruction and disability are not only causing increase in patients' suffering but also contribute to huge economic burden for the society. General increase in life expectancy and high prevalence of these diseases both in elderly and younger population emphasize the importance of developing safe and effective vaccines. In this review, at first the possible mechanisms and risk factors associated with chronic inflammatory autoimmune diseases, such as rheumatoid arthritis (RA), multiple sclerosis (MS), systemic lupus erythematosus (SLE) and type 1 diabetes (T1D) are discussed. Current advances in the development of vaccines for such autoimmune diseases, particularly those based on DNA, altered peptide ligands and peptide loaded MHC II complexes are discussed in detail. Finally, strategies for improving the efficacy of potential vaccines are explored.
慢性炎症性自身免疫性疾病导致靶组织破坏和残疾，不仅增加了患者的痛苦，也给社会带来了巨大的经济负担。预期寿命的普遍增加和老年和年轻人群中这些疾病的高患病率都强调了开发安全有效的疫苗的重要性。在这篇综述中，首先讨论了与慢性炎症性自身免疫性疾病（如类风湿关节炎、多发性硬化症、系统性红斑狼疮和 1 型糖尿病）相关的可能机制和风险因素。详细讨论了针对这些自身免疫性疾病的疫苗的最新进展，特别是基于 DNA、改变的肽配体和肽负载 MHC II 复合物的疫苗。最后，探讨了提高潜在疫苗疗效的策略。
