家族成员齐聚： proneural bHLH 基因与神经元多样性。
All in the family: proneural bHLH genes and neuronal diversity.
机构信息
Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461 USA
Department of Cell Biology and Human Anatomy, University of California, One Shields Avenue, Davis, CA 95616 USA
出版信息
Development. 2018 May 2;145(9):dev159426. doi: 10.1242/dev.159426.
Abstract
Proneural basic Helix-Loop-Helix (bHLH) proteins are required for neuronal determination and the differentiation of most neural precursor cells. These transcription factors are expressed in vastly divergent organisms, ranging from sponges to primates. Here, we review proneural bHLH gene evolution and function in the and vertebrate nervous systems, arguing that the gene provides a useful platform for understanding proneural gene structure and regulation. We also discuss how functional equivalency experiments using distinct proneural genes can reveal how proneural gene duplication and divergence are interwoven with neuronal complexity.
摘要
神经前体细胞基本螺旋-环-螺旋（bHLH）蛋白对于神经元的确定和大多数神经前体细胞的分化是必需的。这些转录因子在从海绵动物到灵长类动物的广泛不同的生物体中表达。在这里，我们回顾了神经前体细胞 bHLH 基因在 和脊椎动物神经系统中的进化和功能，认为 基因 为理解神经前体细胞基因结构和调控提供了一个有用的平台。我们还讨论了如何使用不同的神经前体细胞基因进行功能等效性实验，可以揭示神经前体细胞基因复制和分化是如何与神经元复杂性交织在一起的。
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