Wilke Skadi, Prehn Kristin, Taud Benedikt, List Jonathan, Flöel Agnes
Department of Neurology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Center for Stroke Research Berlin, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
J Clin Med. 2018 May 1;7(5):95. doi: 10.3390/jcm7050095.
Recurrent mild traumatic brain injuries (mTBI) and its neurological sequelae have been the focus of a large number of studies, indicating cognitive, structural, and functional brain alterations. However, studies often focused on single outcome measures in small cohorts of specific populations only. We conducted a multimodal evaluation of the impact of recurrent mTBI on a broad range of cognitive functions, regional brain volume, white matter integrity, and resting state functional connectivity (RSFC) in young and older adults in the chronic stage (>6 months after the last mTBI). Seventeen young participants with mTBI (age: 24.2 ± 2.8 (mean ± SD)) and 21 group-wise matched healthy controls (age: 25.8 ± 5.4 (mean ± SD)), as well as 17 older participants with mTBI (age: 62.7 ± 7.7 (mean ± SD)) and 16 group-wise matched healthy controls (age: 61.7 ± 5.9 (mean ± SD)) were evaluated. We found significant differences in the verbal fluency between young participants with mTBI and young healthy controls. Furthermore, differences in the regional volume of precuneus and medial orbitofrontal gyrus between participants with mTBI and controls for both age groups were seen. A significant age by group interaction for the right hippocampal volume was noted, indicating an accelerated hippocampal volume loss in older participants with mTBI. Other cognitive parameters, white matter integrity, and RSFC showed no significant differences. We confirmed some of the previously reported detrimental effects of recurrent mTBI, but also demonstrated inconspicuous findings for the majority of parameters.
反复轻度创伤性脑损伤（mTBI）及其神经后遗症一直是大量研究的重点，这些研究表明大脑在认知、结构和功能方面存在改变。然而，以往研究往往仅聚焦于特定人群的小样本队列中的单一结果指标。我们对反复发生的mTBI对慢性期（最后一次mTBI后>6个月）的年轻人和老年人广泛认知功能、脑区体积、白质完整性和静息态功能连接（RSFC）的影响进行了多模态评估。评估了17名患有mTBI的年轻参与者（年龄：24.2±2.8（均值±标准差））和21名按组匹配的健康对照者（年龄：25.8±5.4（均值±标准差）），以及17名患有mTBI的老年参与者（年龄：62.7±7.7（均值±标准差））和16名按组匹配的健康对照者（年龄：61.7±5.9（均值±标准差））。我们发现患有mTBI的年轻参与者与年轻健康对照者在言语流畅性方面存在显著差异。此外，在两个年龄组中，患有mTBI的参与者与对照者之间在楔前叶和眶额内侧回的区域体积上也存在差异。注意到右侧海马体积存在显著的年龄与组间交互作用，表明患有mTBI的老年参与者海马体积加速丢失。其他认知参数、白质完整性和RSFC未显示出显著差异。我们证实了先前报道的反复发生的mTBI的一些有害影响，但也表明大多数参数的结果并不明显。
