Institute of Organic Chemistry , University of Münster , Corrensstrasse 40 , 48149 Münster , Germany.
J Am Chem Soc. 2018 May 23;140(20):6221-6225. doi: 10.1021/jacs.8b03333. Epub 2018 May 15.
A method for transition metal-free 1,2-carboboration of unactivated alkenes with bis(catecholato)diboron as the boron source in combination with alkyl halides as the alkyl component is introduced. The three-component reaction proceeds via a radical pathway on a broad range of unactivated alkenes, and the 1,2-carboboration products serve as valuable synthetic building blocks. Density functional theory calculations provide insights into the mechanism.
本文介绍了一种在无金属条件下，利用双（邻苯二酚）二硼作为硼源，与卤代烷烃作为烷基组分，对未活化烯烃进行 1,2-碳硼化的方法。该三组分反应在广泛的未活化烯烃上通过自由基途径进行，1,2-碳硼化产物可作为有价值的合成砌块。密度泛函理论计算提供了对反应机制的深入了解。
