Key Laboratory of Hepatosplenic Surgery and the First Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Department of Spine Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Mater Sci Eng C Mater Biol Appl. 2018 Aug 1;89:456-469. doi: 10.1016/j.msec.2018.04.062. Epub 2018 Apr 22.
Tissue engineering (TE) is an emerging and promising strategy to heal tissue failure by integrating science and technology of materials, cells and growth factors. With the increasing of aging population, restoring musculoskeletal tissue has become the focus of TE. Among various materials tested in TE, silk fibroin (SF) is increasingly being recognized as a promising material. SF, a natural protein polymer with excellent physiochemical characteristics, has established a good reputation in terms of musculoskeletal tissue engineering (MTE). The present article provides an overview of SF and introduces various approaches of fabricating SF-based biomaterial followed by their applications in MTE.
组织工程（TE）是一种新兴且有前途的策略，通过整合材料、细胞和生长因子的科学和技术来治愈组织衰竭。随着人口老龄化的增加，恢复肌肉骨骼组织已成为 TE 的重点。在 TE 中测试的各种材料中，丝素蛋白（SF）越来越被认为是一种有前途的材料。SF 是一种具有优异理化特性的天然蛋白质聚合物，在肌肉骨骼组织工程（MTE）方面享有良好的声誉。本文概述了 SF，并介绍了制造基于 SF 的生物材料的各种方法，以及它们在 MTE 中的应用。
