Hruskova Jana, Maugeri Andrea, Podroužková Helena, Štípalová Tatiana, Jakubík Juraj, Barchitta Martina, Medina-Inojosa Jose R, Homolka Martin, Agodi Antonella, Kunzova Sarka, Sochor Ondrej, Lopez-Jimenez Francisco, Vinciguerra Manlio
International Clinical Research Center, St'Anne University Hospital, Brno 60200, Czech Republic.
Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, 95123 Catania, Italy.
J Clin Med. 2018 May 13;7(5):113. doi: 10.3390/jcm7050113.
Intima-media thickness (IMT) has been proposed as a measurement of subclinical atherosclerosis and has been associated with cardiovascular disease (CVD). Epicardial adipose tissue (EAT) is a fat depot between the pericardium and myocardium and has been associated with coronary atherosclerosis. The relationship between IMT and EAT thickness has not been reported before. We investigated the relationship between EAT thickness, IMT, CVD risk factors, and ideal cardiovascular health (CVH) metrics using subjects from the Kardiovize Brno 2030 cohort study, a random urban sample population in Central Europe. We studied 102 individuals (65 males) aged 25⁻64 years (median = 37 years) with no current or past CVD history. We measured IMT using a vascular ultrasound and EAT thickness using transthoracic echocardiography, and collected data on anthropometric factors, CVD risk factors, and CVH score. Correlation tests and multiple linear regression models were applied. In the age- and gender-adjusted model, we demonstrated that, among CVD risk factors, only BMI was significantly and positively associated with EAT thickness (β = 0.182, SE = 0.082, = 0.030), while no significant associations with IMT were evident. Although both EAT thickness and IMT were negatively correlated with CVH score ( = −0.45, < 0.001, and = −0.38, < 0.001, respectively), we demonstrated that overall CVH score (β = −0.262; SE = 0.077; = 0.001), as well as BMI (β = −1.305; SE = 0.194; < 0.001) and blood pressure CVH metrics (β = −0.607; SE = 0.206; = 0.004) were significantly associated with EAT thickness but not with IMT. Our study is important as it demonstrated for the first time that CVH is associated with EAT thickness. Interestingly, this relationship seems to be dependent on BMI and blood pressure rather than on the other CVH metrics. However, outcome-driven studies are required to confirm these findings.
内膜中层厚度（IMT）已被提议作为亚临床动脉粥样硬化的一种测量指标，并且与心血管疾病（CVD）相关。心外膜脂肪组织（EAT）是心包和心肌之间的一个脂肪储存库，与冠状动脉粥样硬化有关。IMT与EAT厚度之间的关系此前尚未见报道。我们利用来自中欧一个随机城市样本人群的Kardiovize布尔诺2030队列研究中的受试者，研究了EAT厚度、IMT、CVD危险因素和理想心血管健康（CVH）指标之间的关系。我们研究了102名年龄在25至64岁（中位数 = 37岁）且无当前或既往CVD病史的个体（65名男性）。我们使用血管超声测量IMT，使用经胸超声心动图测量EAT厚度，并收集了人体测量因素、CVD危险因素和CVH评分的数据。应用了相关性检验和多元线性回归模型。在年龄和性别调整模型中，我们证明，在CVD危险因素中，只有BMI与EAT厚度显著正相关（β = 0.182，标准误 = 0.082，P = 0.030），而与IMT无明显关联。尽管EAT厚度和IMT均与CVH评分呈负相关（分别为r = -0.45，P < 0.001和r = -0.38，P < 0.001），但我们证明总体CVH评分（β = -0.262；标准误 = 0.077；P = 0.001）以及BMI（β = -1.305；标准误 = 0.194；P < 0.001）和血压CVH指标（β = -0.607；标准误 = 0.206；P = 0.004）与EAT厚度显著相关，但与IMT无关。我们的研究很重要，因为它首次证明了CVH与EAT厚度相关。有趣的是，这种关系似乎取决于BMI和血压，而不是其他CVH指标。然而，需要进行结果驱动的研究来证实这些发现。
