在鸡场分离的大肠杆菌中，多粘菌素耐药基因与质粒上的一个变体共存。
Colocation of the Polymyxin Resistance Gene and a Variant of on a Plasmid in an Escherichia coli Isolate from a Chicken Farm.
机构信息
Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan, People's Republic of China
出版信息
Antimicrob Agents Chemother. 2018 May 25;62(6). doi: 10.1128/AAC.00501-18. Print 2018 Jun.
Abstract
A colistin-resistant isolate from a commercial poultry farm in China carried two colistin resistance genes, and variant of , in an IncP plasmid. The variant of the gene, named , encoded two amino acid substitutions compared with the gene. A novel genetic structure, IS-IS, might be the key element mediating the translocation of through the formation of a circular form. The and genes, which are colocated on a plasmid, might pose a huge threat to public health.
摘要
从中国一家商业家禽养殖场分离的一株粘菌素耐药菌，在一个 IncP 质粒上携带两个粘菌素耐药基因 mcr-1 和 mcr-3 的变体。mcr-3 基因的变体命名为 mcr-3.1，与 mcr-3 基因相比，编码两个氨基酸的替换。IS-IS 可能是一种新的遗传结构，是介导 mcr-3 通过形成环形形式转移的关键因素。位于质粒上的 mcr-1 和 mcr-3 基因可能对公共健康构成巨大威胁。
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