She S C, Peyman G A, Schulman J A
LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans.
Int Ophthalmol. 1988;12(2):151-4. doi: 10.1007/BF00137142.
Foscarnet (sodium phosphonoformate) is an antiviral with a high degree of efficacy against members of the herpes simplex virus family. We studied the toxicity of single doses of intravitreally administered foscarnet in the albino rabbit. Eyes were evaluated clinically and by light microscopy. Data demonstrated that doses ranging from 20 to 1000 micrograms per 0.1 milliliter are nontoxic to the retina, suggesting that foscarnet may be useful in the treatment of acute retinal necrosis and cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome.
膦甲酸（膦甲酸钠）是一种对单纯疱疹病毒家族成员具有高度疗效的抗病毒药物。我们研究了对白化兔玻璃体内单次注射膦甲酸的毒性。通过临床和光学显微镜对眼睛进行评估。数据表明，每0.1毫升20至1000微克的剂量对视网膜无毒，这表明膦甲酸可能对获得性免疫缺陷综合征患者的急性视网膜坏死和巨细胞病毒性视网膜炎的治疗有用。
