School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China.
Molecules. 2018 May 17;23(5):1199. doi: 10.3390/molecules23051199.
Semen Cuscutae is commonly used in traditional Chinese medicine and contains a series of compounds such as flavonoids, chlorogenic acids and lignans. In this study, we identified different kinds of compositions by ultra-high-performance liquid chromatography (UPLC) coupled to electrospray ionization mass spectrometry (MS). A total of 45 compounds were observed, including 20 chlorogenic acids, 23 flavonoids and 2 lignans. 23 of them are reported for the first time including 6--caffeoyl--glucose, 3--(4'--Caffeoylglucosyl) quinic acid, etc. Their structures were established by retention behavior, extensive analyses of their MS spectra and further determined by comparison of their MS data with those reported in the literature. As chlorogenic acids and flavonoids are phenolic compounds that are predominant in Semen Cuscutae, in conclusion, phenolic compounds are the major constituents of Semen Cuscutae.
菟丝子在中医药中被广泛应用，包含一系列化合物，如类黄酮、绿原酸和木脂素。在这项研究中，我们通过超高效液相色谱（UPLC）与电喷雾电离质谱（MS）联用，鉴定了不同种类的成分。共观察到 45 种化合物，包括 20 种绿原酸、23 种类黄酮和 2 种木脂素。其中 23 种为首次报道，包括 6--咖啡酰--葡萄糖、3--（4'--咖啡酰基葡萄糖）奎宁酸等。通过保留行为、对其 MS 谱的广泛分析以及通过将其 MS 数据与文献中报道的数据进行比较，确定了它们的结构。由于绿原酸和类黄酮是菟丝子中主要的酚类化合物，因此可以得出结论，酚类化合物是菟丝子的主要成分。
