Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Clin Nutr. 2019 Jun;38(3):1067-1075. doi: 10.1016/j.clnu.2018.04.015. Epub 2018 May 8.
BACKGROUND & AIMS: In the past, some observational studies have been carried out on the relationship between milk and dairy intake and risk of acne occurrence; however, their results were conflicting. This study is a meta-analysis and dose-response analysis designed to evaluate the relationship between milk and dairy products and acne development.
MATERIALS & METHODS: Data of the study were searched and collected from Pubmed/Medline, Scopus, Web of Science, and Embase databases. Study design, sex, age, exposure (i.e. dairy, milk, yogurt, cheese), dietary assessment method, acne ascertainment, total sample size, number of total subjects and cases in each category of exposure intake, OR, RR and PR with 95% CI in each category of exposure intake and adjusted variables were extracted.
Highest compared with lowest category of dairy (OR: 2.61, 95% CI: 1.20 to 5.67), total milk (OR: 1.48, 95% CI: 1.31 to 1.66), low-fat milk (OR: 1.25, 95% CI: 1.10 to 1.43) and skim milk (OR: 1.82, 95% CI: 1.34 to 2.47) intake significantly was associated with the presence of acne. Results of dose-response analysis revealed a significant linear relationship between dairy, whole milk and skim milk and risk of acne and nonlinear association between dairy, milk, low-fat milk and skim milk intake and acne.
In this meta-analysis we found a positive relationship between dairy, total milk, whole milk, low-fat and skim milk consumption and acne occurrence. In contrary, no significant association between yogurt/cheese and acne development was observed.
过去，一些观察性研究已经探讨了牛奶和乳制品摄入与痤疮发生风险之间的关系，但结果存在争议。本研究是一项荟萃分析和剂量-反应分析，旨在评估牛奶和乳制品与痤疮发展之间的关系。
研究数据从 Pubmed/Medline、Scopus、Web of Science 和 Embase 数据库中检索和收集。提取研究设计、性别、年龄、暴露（即乳制品、牛奶、酸奶、奶酪）、饮食评估方法、痤疮确定、总样本量、每个暴露摄入类别的总人数和病例数、每个暴露摄入类别的 OR、RR 和 PR 及其 95%CI 和调整变量。
与最低类别的乳制品（OR：2.61，95%CI：1.20 至 5.67）、总牛奶（OR：1.48，95%CI：1.31 至 1.66）、低脂牛奶（OR：1.25，95%CI：1.10 至 1.43）和脱脂牛奶（OR：1.82，95%CI：1.34 至 2.47）摄入最高类别相比，痤疮的存在显著相关。剂量-反应分析的结果表明，乳制品、全脂牛奶和脱脂牛奶与痤疮风险之间存在显著的线性关系，而乳制品、牛奶、低脂牛奶和脱脂牛奶摄入与痤疮之间存在非线性关系。
在这项荟萃分析中，我们发现乳制品、全脂牛奶、脱脂牛奶和低脂牛奶的摄入与痤疮的发生呈正相关。相反，我们没有发现酸奶/奶酪与痤疮发展之间存在显著关联。
