Rasti Shinta D, Dewinta Nena R, Kamal Ronik H, Adissadah Avina F, Madanny Afhama E, Dewanti Linda
Department of Public Health and Preventive Medicine, Faculty of Medicine, Airlangga University, Kota SBY, Jawa Timur, Indonesia.
Indian J Dermatol. 2022 Jan-Feb;67(1):31-36. doi: 10.4103/ijd.ijd_871_21.
Vitamin D is thought to play a role in the pathogenesis of acne, and its levels can change in patients with acne vulgaris. Several studies have revealed that serum 25-hydroxy vitamin D levels tend to be low and statistically significant in acne vulgaris patients. However, the relationship between vitamin D levels and acne severity is still poorly understood.
This study aims to identify the correlation between serum 25-hydroxy vitamin D levels and the severity of acne vulgaris.
This systematic review study was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guideline based on several studies taken from the PubMed, PMC, Semantic Scholar, and ResearchGate databases until June 2021. Full-text case-control, randomized controlled trial, or cross-sectional study in English or Indonesian language reporting on the serum 25-hydroxy vitamin D levels and the severity of acne vulgaris on human participants were included.
From a total of 401 studies, 10 studies met the criteria. Almost all studies (8 of 10) revealed lower serum 25-hydroxy vitamin D levels as the acne severity progresses, although 2 of them were not statistically significant.
The evidence of an inverse correlation between serum 25-hydroxy vitamin D levels and the severity of acne vulgaris suggests the need for screening of vitamin D levels in acne patients and offers a new prospect in the field of acne prevention and treatment.
维生素D被认为在痤疮发病机制中起作用，寻常痤疮患者体内的维生素D水平会发生变化。多项研究表明，寻常痤疮患者的血清25-羟维生素D水平往往较低，且具有统计学意义。然而，维生素D水平与痤疮严重程度之间的关系仍未得到充分了解。
本研究旨在确定血清25-羟维生素D水平与寻常痤疮严重程度之间的相关性。
本系统评价研究遵循系统评价和Meta分析的首选报告项目（PRISMA）指南，基于截至2021年6月从PubMed、PMC、Semantic Scholar和ResearchGate数据库获取的多项研究进行。纳入以英文或印尼文报告人类参与者血清25-羟维生素D水平和寻常痤疮严重程度的全文病例对照研究、随机对照试验或横断面研究。
在总共401项研究中，有10项研究符合标准。几乎所有研究（10项中的8项）都显示，随着痤疮严重程度的增加，血清25-羟维生素D水平降低，不过其中2项研究无统计学意义。
血清25-羟维生素D水平与寻常痤疮严重程度呈负相关的证据表明，有必要对痤疮患者进行维生素D水平筛查，并为痤疮预防和治疗领域提供了新的前景。
