da Silva Felipe Rodolfo Pereira, Pessoa Larissa Dos Santos, Vasconcelos Any Carolina Cardoso Guimarães, de Aquino Lima Weberson, Alves Even Herlany Pereira, Vasconcelos Daniel Fernando Pereira
Laboratory of Histological Analysis and Preparation (LAPHIS), Federal University of Piaui, Parnaiba, PI, Brazil.
Medicine School, Education Institute of Parnaiba Valley (IESVAP), Parnaiba, PI, Brazil.
Mol Biol Rep. 2017 Dec;44(6):443-453. doi: 10.1007/s11033-017-4128-x. Epub 2017 Oct 13.
Polymorphisms in inflammatory genes such as interleukins 17A and 17F are associated with the risk of development of periodontitis, although the results remain contradictory. Hence, the aim of this study was perform a meta-analysis focusing on two polymorphisms (rs2275913 and rs763780) in interleukins 17A and 17F genes, respectively, in both chronic (CP) and aggressive periodontitis (AgP). A review in literature was performed in several databases for studies published before 25, September 2016. The meta-analysis was obtained through the review manager statistical software (version 5.2) with odds ratio (OR) calculation and funnel plot (P < 0.05) for heterogeneity, as well as the comprehensive meta-analysis software (version 3.3.070) for the assessment of publication bias. Seven articles with 1540 participants composed the results in which the mutant allele in the rs2275913 polymorphism did not present significant association with the risk of CP or AgP (OR 1.56, 95% CI 0.77, 3.15, P = 0.21; OR 1.12, 95% CI 0.05, 23.44, P = 0.94, respectively) nor was the mutant allele in rs763780 associated with the risk of CP (OR 1.19, 95% CI 0.80, 1.76, P = 0.39) or AgP (OR 1.07, 95% CI 0.63, 1.84, P = 0.79). No bias of publication was observed by Egger's and Begg's tests in any allelic evaluation. This meta-analysis showed a non-significant association between the polymorphisms rs2275913 and rs763780 in interleukins 17A and 17F genes and chronic and aggressive periodontitis in the allelic evaluation.
诸如白细胞介素17A和17F等炎症基因的多态性与牙周炎的发生风险相关，尽管结果仍存在矛盾。因此，本研究的目的是针对白细胞介素17A和17F基因中的两种多态性（rs2275913和rs763780）分别在慢性牙周炎（CP）和侵袭性牙周炎（AgP）中进行一项荟萃分析。在多个数据库中对2016年9月25日前发表的研究进行了文献综述。通过综述管理器统计软件（版本5.2）计算比值比（OR）并绘制漏斗图（P < 0.05）以评估异质性，以及使用综合荟萃分析软件（版本3.3.070）评估发表偏倚，从而进行荟萃分析。七篇文章共1540名参与者构成了研究结果，其中rs2275913多态性中的突变等位基因与CP或AgP的风险均无显著关联（OR分别为1.56，95% CI为0.77，3.15，P = 0.21；OR为1.12，95% CI为0.05，23.44，P = 0.94），rs763780中的突变等位基因也与CP（OR为1.19，95% CI为0.80，1.76，P = 0.39）或AgP（OR为1.07，95% CI为0.63，1.84，P = 0.79）的风险无关。在任何等位基因评估中，通过Egger检验和Begg检验均未观察到发表偏倚。这项荟萃分析表明，在等位基因评估中，白细胞介素17A和17F基因中的rs2275913和rs763780多态性与慢性和侵袭性牙周炎之间无显著关联。
