Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040 Madrid, Spain.
Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
FEMS Microbiol Rev. 2018 Sep 1;42(5):627-638. doi: 10.1093/femsre/fuy022.
Microbial cells do not live in isolation in their environment, but rather they communicate with each other using chemical signals. This sophisticated mode of cell-to-cell signalling, known as quorum sensing, was first discovered in bacteria, and coordinates the behaviour of microbial population behaviour in a cell-density-dependent manner. More recently, these mechanisms have been described in eukaryotes, particularly in fungi, where they regulate processes such as pathogenesis, morphological differentiation, secondary metabolite production and biofilm formation. In this manuscript, we review the information available to date on these processes in yeast, dimorphic fungi and filamentous fungi. We analyse the diverse chemical 'languages' used by different groups of fungi, their possible cross-talk and interkingdom interactions with other organisms. We discuss the existence of these mechanisms in multicellular organisms, the ecophysiological role of QS in fungal colonisation and the potential applications of these mechanisms in biotechnology and pathogenesis.
微生物细胞并非在其所处的环境中孤立生存，而是通过化学信号相互交流。这种复杂的细胞间信号传递方式被称为群体感应，最初在细菌中被发现，它以细胞密度依赖的方式协调微生物种群行为。最近，这些机制在真核生物中，特别是在真菌中被描述，它们调节着发病机制、形态分化、次生代谢产物产生和生物膜形成等过程。在本文中，我们综述了目前关于酵母、二相性真菌和丝状真菌中这些过程的信息。我们分析了不同真菌群体使用的不同化学“语言”、它们可能的交叉对话以及与其他生物体的种间相互作用。我们讨论了这些机制在多细胞生物中的存在、QS 在真菌定殖中的生态生理学作用以及这些机制在生物技术和发病机制中的潜在应用。
