Key Laboratory of Geriatric Nutrition and Health, Ministry of Education, Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing, China.
J Basic Microbiol. 2023 Oct;63(10):1073-1084. doi: 10.1002/jobm.202200721. Epub 2023 Jun 26.
Quorum sensing (QS) is a communication mechanism between microorganisms originally found in bacteria. In recent years, an important QS mechanism has been discovered in the field of fungi, namely, the lipoxygenase compound oxylipin of arachidonic acid acts as a QS molecule in life cycle control, particularly in the sexual and asexual development of fungi. However, the role of oxylipins in mediating eukaryotic communication has not been previously described. In this paper, we review the regulatory role of oxylipins and the underlying mechanisms and discuss the potential for application in major fungi. The role of oxylipin as a fungal quorum-sensing molecule is the main focus of the review. Besides, the quorum regulation of fungal morphological transformation, biofilm formation, virulence factors, secondary metabolism, infection, symbiosis, and other physiological behaviors are discussed. Moreover, future prospectives and applications are elaborated as well.
群体感应 (QS) 是一种最初在细菌中发现的微生物之间的通信机制。近年来，在真菌领域发现了一种重要的 QS 机制，即花生四烯酸的脂氧合酶化合物氧化脂素作为一种 QS 分子在生命周期控制中起作用，特别是在真菌的有性和无性发育中。然而，氧化脂素在介导真核生物通信中的作用以前尚未被描述。在本文中，我们综述了氧化脂素的调节作用及其潜在的机制，并讨论了在主要真菌中的应用潜力。本文重点介绍了氧化脂素作为真菌群体感应分子的作用。此外，还讨论了真菌形态转化、生物膜形成、毒力因子、次生代谢、感染、共生和其他生理行为的群体调节。此外，还阐述了未来的前景和应用。
