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库蚊属黄病毒感染蚊群及其对裂谷热病毒媒介效能的影响。

Culex flavivirus infection in a Culex pipiens mosquito colony and its effects on vector competence for Rift Valley fever phlebovirus.

机构信息

IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.

Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.

出版信息

Parasit Vectors. 2018 May 23;11(1):310. doi: 10.1186/s13071-018-2887-4.

DOI:10.1186/s13071-018-2887-4
PMID:29792223
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5966921/
Abstract

BACKGROUND

Rift Valley fever is a mosquito-borne zoonotic disease that affects domestic ruminants and humans. Culex flavivirus is an insect-specific flavivirus that naturally exists in field mosquito populations. The influence of Culex flavivirus on Rift Valley fever phlebovirus (RVFV) vector competence of Culex pipiens has not been investigated.

METHODS

Culex flavivirus infection in a Cx. pipiens colony was studied by Culex flavivirus oral feeding and intrathoracical inoculation. Similarly, vector competence of Cx. pipiens infected with Culex flavivirus was evaluated for RVFV. Infection, dissemination, transmission rates and transmission efficiency of Culex flavivirus-infected and non-infected Cx. pipiens artificially fed with RVFV infected blood were assessed.

RESULTS

Culex flavivirus was able to infect Cx. pipiens after intrathoracically inoculation in Cx. pipiens mosquitos but not after Culex flavivirus oral feeding. Culex flavivirus did not affect RVFV infection, dissemination and transmission in Cx. pipiens mosquitoes. RVFV could be detected from saliva of both the Culex flavivirus-positive and negative Cx. pipiens females without significant differences. Moreover, RVFV did not interfere with the Culex flavivirus infection in Cx. pipiens mosquitoes.

CONCLUSIONS

Culex flavivirus infected and non-infected Cx. pipiens transmit RVFV. Culex flavivirus existing in field-collected Cx. pipiens populations does not affect their vector competence for RVFV. Culex flavivirus may not be an efficient tool for RVFV control in mosquitoes.

摘要

背景

裂谷热是一种蚊媒性人畜共患病，影响家畜反刍动物和人类。库蚊黄病毒是一种昆虫特异性黄病毒，自然存在于野外蚊虫种群中。库蚊黄病毒对裂谷热病毒（RVFV）载体对库蚊（Culex pipiens）的感染力的影响尚未得到研究。

方法

通过库蚊黄病毒口服和胸腔内接种研究库蚊种群中的库蚊黄病毒感染。同样，评估了感染库蚊黄病毒的库蚊对 RVFV 的媒介能力。评估了人工喂食 RVFV 感染血液的感染、传播、感染和传播效率。

结果

库蚊黄病毒能够在 Cx. pipiens 蚊子中通过胸腔内接种感染，但不能通过库蚊黄病毒口服感染。库蚊黄病毒不会影响 RVFV 在库蚊中的感染、传播和传播。RVFV 可从 Culex flavivirus 阳性和阴性 Cx. pipiens 雌性的唾液中检测到，没有明显差异。此外，RVFV 不会干扰 Cx. pipiens 蚊子中的库蚊黄病毒感染。

结论

感染和未感染库蚊黄病毒的库蚊均可传播 RVFV。在野外采集的库蚊种群中存在的库蚊黄病毒不会影响其对 RVFV 的媒介能力。库蚊黄病毒可能不是控制蚊子中 RVFV 的有效工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e89/5966921/acf4d424d180/13071_2018_2887_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e89/5966921/71b73238c749/13071_2018_2887_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e89/5966921/0bcaa583d304/13071_2018_2887_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e89/5966921/e9c662a705ed/13071_2018_2887_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e89/5966921/acf4d424d180/13071_2018_2887_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e89/5966921/71b73238c749/13071_2018_2887_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e89/5966921/0bcaa583d304/13071_2018_2887_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e89/5966921/e9c662a705ed/13071_2018_2887_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e89/5966921/acf4d424d180/13071_2018_2887_Fig4_HTML.jpg

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