Manzanero Silvia, Kozlovskaia Maria, Vlahovich Nicole, Hughes David C
Australian Institute of Sport, Department of Sports Medicine, Australian Sports Commission, Bruce, Australia.
Research Institute for Sport and Exercise, University of Canberra, Bruce, Australia.
JMIR Res Protoc. 2018 May 23;7(5):e141. doi: 10.2196/resprot.8243.
With the increasing capacity for remote collection of both data and samples for medical research, a thorough assessment is needed to determine the association of population characteristics and recruitment methodologies with response rates.
The aim of this research was to assess population representativeness in a two-stage study of health and injury in recreational runners, which consisted of an epidemiological arm and genetic analysis.
The cost and success of various classical and internet-based methods were analyzed, and demographic representativeness was assessed for recruitment to the epidemiological survey, reported willingness to participate in the genetic arm of the study, actual participation, sample return, and approval for biobank storage.
A total of 4965 valid responses were received, of which 1664 were deemed eligible for genetic analysis. Younger age showed a negative association with initial recruitment rate, expressed willingness to participate in genetic analysis, and actual participation. Additionally, female sex was associated with higher initial recruitment rates, and ethnic origin impacted willingness to participate in the genetic analysis (all P<.001).
The sharp decline in retention through the different stages of the study in young respondents suggests the necessity to develop specific recruitment and retention strategies when investigating a young, physically active population.
随着医学研究中数据和样本远程收集能力的不断提高，需要进行全面评估，以确定人群特征和招募方法与应答率之间的关联。
本研究旨在评估一项针对休闲跑步者健康与损伤的两阶段研究中的人群代表性，该研究包括一个流行病学分支和基因分析。
分析了各种传统方法和基于互联网方法的成本与成功率，并评估了流行病学调查招募的人口统计学代表性、报告的参与研究基因分支的意愿、实际参与情况、样本返回情况以及生物样本库储存批准情况。
共收到4965份有效回复，其中1664份被认为符合基因分析条件。年龄较小与初始招募率、表示愿意参与基因分析以及实际参与呈负相关。此外，女性与较高的初始招募率相关，种族影响参与基因分析的意愿（所有P<0.001）。
在年轻受访者中，研究不同阶段的保留率急剧下降，这表明在调查年轻、身体活跃的人群时，有必要制定特定的招募和保留策略。
