University of Pennsylvania, 380 S. University Avenue, Philadelphia, PA 19104, United States.
University of Pennsylvania, 380 S. University Avenue, Philadelphia, PA 19104, United States.
Matrix Biol. 2019 May;78-79:201-218. doi: 10.1016/j.matbio.2018.05.007. Epub 2018 May 21.
Cardiovascular disease (CVD) due to atherosclerosis is a disease of chronic inflammation at both the systemic and the tissue level. CD44 has previously been implicated in atherosclerosis in both humans and mice. This multi-faceted receptor plays a critical part in the inflammatory response during the onset of CVD, though little is known of CD44's role during the latter stages of the disease. This review focuses on the role of CD44-dependent HA-dependent effects on inflammatory cells in several key processes, from disease initiation throughout the progression of atherosclerosis. Understanding how CD44 and HA regulate inflammation in atherogenesis is key in determining the utility of the CD44-HA axis as a therapeutic target to halt disease and potentially promote disease regression.
心血管疾病（CVD）是由于动脉粥样硬化引起的系统性和组织水平的慢性炎症性疾病。CD44 先前已被牵连到人类和小鼠的动脉粥样硬化中。这种多方面的受体在 CVD 发病期间的炎症反应中起着关键作用，尽管对 CD44 在疾病后期的作用知之甚少。本综述重点介绍了 CD44 依赖性 HA 依赖性作用对几种关键过程中炎症细胞的影响，从疾病的起始到动脉粥样硬化的进展。了解 CD44 和 HA 如何调节动脉粥样硬化中的炎症是确定 CD44-HA 轴作为阻止疾病和可能促进疾病消退的治疗靶点的效用的关键。
