Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100005, China.
Cell Mol Immunol. 2019 Jan;16(1):1-5. doi: 10.1038/s41423-018-0042-y. Epub 2018 May 23.
The metabolic control of immune cell development and function has been shown to be critical for the maintenance of immune homeostasis and is also involved in the pathogenesis of immune disorders. Pathogenic infections or cancers may induce metabolic reprogramming through different pathways to meet the energy and metabolite demands for pathogen propagation or cancer progression. In addition, some deregulated metabolites could trigger or regulate immune responses, thus causing chronic inflammation or immune disorders, such as viral infection, cancer and obesity. Therefore, the methods through which metabolism is regulated and the role of metabolic regulation in inflammation and immunity attract much attention. Epigenetic regulation of inflammation and immunity is an emerging field. Long noncoding RNAs (lncRNAs) have been well documented to play crucial roles in many biological processes through diverse mechanisms, including immune regulation and metabolic alternation. Here, we review the functions and mechanisms of lncRNAs in the metabolic regulation of inflammatory immune disorders, aiming to deepen our understanding of the epigenetic regulation of inflammation and immunity.
免疫细胞发育和功能的代谢控制对于维持免疫稳态至关重要，并且也参与了免疫紊乱的发病机制。致病感染或癌症可能通过不同的途径诱导代谢重编程，以满足病原体繁殖或癌症进展的能量和代谢物需求。此外，一些失调的代谢物可以触发或调节免疫反应，从而导致慢性炎症或免疫紊乱，如病毒感染、癌症和肥胖。因此，代谢调节的方法以及代谢调节在炎症和免疫中的作用引起了广泛关注。炎症和免疫的表观遗传调控是一个新兴领域。长链非编码 RNA（lncRNA）已被充分证明通过多种机制（包括免疫调节和代谢改变）在许多生物学过程中发挥关键作用。在这里，我们综述了 lncRNA 在炎症性免疫紊乱的代谢调控中的功能和机制，旨在加深我们对炎症和免疫的表观遗传调控的理解。
