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2009-2015 年香港纵向血清流行病学研究中 A(H3N2) 流感病毒感染的发生率。

Incidence of influenza A(H3N2) virus infections in Hong Kong in a longitudinal sero-epidemiological study, 2009-2015.

机构信息

WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region, China.

Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China.

出版信息

PLoS One. 2018 May 24;13(5):e0197504. doi: 10.1371/journal.pone.0197504. eCollection 2018.

DOI:10.1371/journal.pone.0197504
PMID:29795587
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5967746/
Abstract

BACKGROUND

Many serologic studies were done during and after the 2009 influenza pandemic, to estimate the cumulative incidence of influenza A(H1N1)pdm09 virus infections, but there are few comparative estimates of the incidence of influenza A(H3N2) virus infections during epidemics.

METHODS

We conducted a longitudinal serologic study in Hong Kong. We collected sera annually and tested samples from 2009-13 by HAI against the A/Perth/16/2009(H3N2) virus, and samples from 2013-15 against the A/Victoria/361/2011(H3N2) virus using the hemagglutination inhibition (HAI) assay. We estimated the cumulative incidence of infections based on 4-fold or greater rises in HAI titers in consecutive sera.

RESULTS

There were four major H3N2 epidemics: (1) Aug-Oct 2010; (2) Mar-Jun 2012; (3) Jul-Oct 2013; and (4) Jun-Jul 2014. Between 516 and 619 relevant pairs of sera were available for each epidemic. We estimated that 9%, 19%, 7% and 7% of the population were infected in each epidemic, respectively, with higher incidence in children in epidemics 1 and 4.

CONCLUSIONS

We found that re-infections in each of the four H3N2 epidemics that occurred from 2010 through 2014 were rare. The largest H3N2 epidemic occurred with the lowest level of pre-epidemic immunity.

摘要

背景

在 2009 年流感大流行期间和之后进行了许多血清学研究，以估计甲型 H1N1pdm09 病毒感染的累积发生率，但在流行期间对甲型 H3N2 病毒感染的发病率进行比较估计的研究很少。

方法

我们在香港进行了一项纵向血清学研究。我们每年采集血清，并使用血凝抑制（HAI）试验分别于 2009 年至 2013 年检测针对 A/Perth/16/2009（H3N2）病毒的样本，以及于 2013 年至 2015 年检测针对 A/Victoria/361/2011（H3N2）病毒的样本。我们根据连续血清中 HAI 滴度增加 4 倍或以上来估计感染的累积发生率。

结果

有四次主要的 H3N2 流行：（1）2010 年 8 月至 10 月；（2）2012 年 3 月至 6 月；（3）2013 年 7 月至 10 月；和（4）2014 年 6 月至 7 月。每个流行期都有 516 至 619 对相关血清样本。我们估计，每个流行期中分别有 9%、19%、7%和 7%的人群感染，在第 1 和第 4 次流行中儿童的发病率更高。

结论

我们发现，2010 年至 2014 年发生的四次 H3N2 流行中，再感染都很罕见。最大的 H3N2 流行发生在流行前免疫力最低的时期。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/5967746/e40c74fd25c8/pone.0197504.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/5967746/1bc087f6ffce/pone.0197504.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/5967746/77475791d2b7/pone.0197504.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/5967746/a4b8bc4235c5/pone.0197504.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/5967746/e40c74fd25c8/pone.0197504.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/5967746/1bc087f6ffce/pone.0197504.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/5967746/77475791d2b7/pone.0197504.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/5967746/a4b8bc4235c5/pone.0197504.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/5967746/e40c74fd25c8/pone.0197504.g004.jpg

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