双氢青蒿素/哌喹和氯喹治疗和阻断传播对柬埔寨间日疟原虫疟疾的疗效。
Therapeutic and Transmission-Blocking Efficacy of Dihydroartemisinin/Piperaquine and Chloroquine against Plasmodium vivax Malaria, Cambodia.
出版信息
Emerg Infect Dis. 2018 Aug;24(8):1516-1519. doi: 10.3201/eid2408.170768. Epub 2018 Aug 17.
Abstract
We assessed the efficacy of standard 3-day courses of chloroquine and dihydroartemisinin/piperaquine against Plasmodium vivax malaria. Compared with chloroquine, dihydroartemisinin/piperaquine was faster in clearing asexual P. vivax parasites and blocking human-to-mosquito transmission. This drug combination was also more effective in preventing potential recurrences for >2 months.
摘要
我们评估了标准的 3 天疗程氯喹和双氢青蒿素/哌喹治疗间日疟原虫疟疾的疗效。与氯喹相比，双氢青蒿素/哌喹能更快地清除无性期 vivax 疟原虫并阻断人传蚊。这种药物组合在预防潜在复发方面也更有效，超过 2 个月。
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