Emerg Infect Dis. 2018 Aug;24(8):1598-9. doi: 10.3201/eid2408.180588. Epub 2018 Aug 17.
In April 2016, a yellow fever outbreak was detected in Uganda. Removal of contaminating ribosomal RNA in a clinical sample improved the sensitivity of next-generation sequencing. Molecular analyses determined the Uganda yellow fever outbreak was distinct from the concurrent yellow fever outbreak in Angola, improving our understanding of yellow fever epidemiology.
2016 年 4 月,乌干达爆发了黄热病疫情。从临床样本中去除污染的核糖体 RNA 提高了下一代测序的敏感性。分子分析确定乌干达黄热病疫情与同期安哥拉的黄热病疫情不同,这提高了我们对黄热病流行病学的认识。