新合成的α-半乳糖寡糖对葡聚糖硫酸钠诱导的 C57BL/6J 小鼠结肠炎的抗炎作用。
Anti-inflammatory effects of newly synthesized α-galacto-oligosaccharides on dextran sulfate sodium-induced colitis in C57BL/6J mice.
机构信息
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA; College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, People's Republic of China.
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA; Zhejiang University of Technology, Hangzhou 310014, People's Republic of China.
出版信息
Food Res Int. 2018 Jul;109:350-357. doi: 10.1016/j.foodres.2018.04.054. Epub 2018 Apr 24.
α-Galacto-oligosaccharides have been reported to have beneficial health effects. The purpose of this study was to investigate the preventive effects of a newly synthesized α-galacto-oligosaccharide mixture (α-GOSg), as well as raffinose family oligosaccharides (RFOs), on dextran sulfate sodium (DSS)-induced colitis in mice. When administered in drinking water at 0.5% for 15 days, both α-GOSg and RFOs significantly decreased fecal hemoglobin content, partially prevented colon length shortening, reduced the severity of colon inflammation, and attenuated DSS-induced upregulation of cyclooxygenase-2. In addition, the activation of the inflammatory regulator nuclear factor-kappa B was slightly inhibited by α-GOSg. The results showed that the newly synthesized α-GOSg preparation has similar anti-inflammatory activities as RFOs in this colitis model. The anti-inflammatory activity of α-GOSg in humans remains to be investigated.
α-半乳糖寡糖已被报道具有有益的健康影响。本研究的目的是研究一种新合成的 α-半乳糖寡糖混合物（α-GOSg）以及棉子糖家族寡糖（RFOs）对葡聚糖硫酸钠（DSS）诱导的小鼠结肠炎的预防作用。当以 0.5%的浓度添加到饮用水中并连续饮用 15 天时，α-GOSg 和 RFOs 均显著降低粪便血红蛋白含量，部分预防结肠缩短，减轻结肠炎症的严重程度，并减弱 DSS 诱导的环氧合酶-2 的上调。此外，α-GOSg 轻微抑制了炎症调节剂核因子-κB 的激活。结果表明，在这种结肠炎模型中，新合成的 α-GOSg 制剂具有与 RFOs 相似的抗炎活性。α-GOSg 在人类中的抗炎活性仍有待研究。
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