College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou 350116, China.
College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou 350116, China.
Drug Discov Today. 2018 Oct;23(10):1791-1800. doi: 10.1016/j.drudis.2018.05.029. Epub 2018 May 24.
In recent years, photodynamic therapy has been applied in cancer treatment because of its high selectivity and marginal invasion properties. However, the excitation light used has limited ability to penetrate tissue, which creates a stumbling block for its future development. To overcome this, X-rays have been introduced to transmit energy to deeper tissues. Given that a large number of X-ray-induced sensitizers have been designed to facilitate X-ray excitation and generate reactive oxygen species (ROS), this has led to the concept of X-ray-induced photodynamic therapy (X-PDT). After 10 years of development, this treatment now shows good therapeutic effects as well as shortcomings. Going forward, it will be important to improve tumor targeting and a standard deep-seated tumor model should be established.
近年来，光动力疗法因其高选择性和边缘入侵特性而被应用于癌症治疗。然而，所用的激发光穿透组织的能力有限，这为其未来的发展造成了障碍。为了克服这一问题，已经引入了 X 射线将能量传输到更深的组织中。鉴于已经设计了大量的 X 射线诱导敏化剂来促进 X 射线激发和产生活性氧物种 (ROS)，这就产生了 X 射线诱导光动力疗法 (X-PDT) 的概念。经过 10 年的发展，这种治疗方法现在显示出了良好的治疗效果和不足之处。未来，重要的是要提高肿瘤的靶向性，并建立一个标准的深部肿瘤模型。
