Atasoy Halil Ibrahim, Bugdayci Guler
Departments of Pediatrics, Abant Izzet Baysal University, Faculty of Medicine, Golkoy, Bolu, Turkey.
Departments of Biochemistry, Abant Izzet Baysal University, Faculty of Medicine, Golkoy, Bolu, Turkey.
Pediatr Int. 2018 Aug;60(8):703-709. doi: 10.1111/ped.13603. Epub 2018 Jul 10.
Zinc deficiency is thought to be common in children, but its predictive capacity for anemia is unclear. Thus, this study identified zinc deficiency in school children, and investigated the association between zinc status and hemoglobin, together with other estimates of anemia.
For this case-control study, 349 of 483 children between 6.5 and 14.8 years old were included from primary schools in Bolu, Turkey. We measured weight, length, body mass index, and complete blood count with serum zinc, ferritin, vitamin B12 and folate. We investigated the differences between the groups and the effects of independent predictors such as age, gender, ferritin, zinc, vitamin B12 and folate on hemoglobin, on hierarchical multiple regression analysis.
Thirty-eight (10.9%) of 349 children had low serum zinc concentration, and 21 (6.0%) were anemic. There were 12 anemic children in the zinc-deficient group and nine in the zinc-sufficient control group (31.5% vs 2.9%) with similar ferritin levels. On regression analysis, zinc had the strongest association with hemoglobin. On receiver operating characteristic analysis, the cut-off for serum zinc for prediction of anemia was 71.5 μg/dL.
The strongest association of zinc with hemoglobin suggests that low zinc contributed the most to the observed anemia in children.
锌缺乏在儿童中被认为很常见，但其对贫血的预测能力尚不清楚。因此，本研究确定了学龄儿童中的锌缺乏情况，并调查了锌状态与血红蛋白之间的关联，以及其他贫血评估指标。
在这项病例对照研究中，从土耳其博卢的小学纳入了483名6.5至14.8岁儿童中的349名。我们测量了体重、身高、体重指数，并进行了全血细胞计数，同时检测了血清锌、铁蛋白、维生素B12和叶酸。在分层多元回归分析中，我们研究了各组之间的差异以及年龄、性别、铁蛋白、锌、维生素B12和叶酸等独立预测因素对血红蛋白的影响。
349名儿童中有38名（10.9%）血清锌浓度低，21名（6.0%）贫血。锌缺乏组有12名贫血儿童，锌充足的对照组有9名（31.5%对2.9%），铁蛋白水平相似。回归分析显示，锌与血红蛋白的关联最强。在受试者工作特征分析中，预测贫血的血清锌临界值为71.5μg/dL。
锌与血红蛋白的最强关联表明，低锌对儿童中观察到的贫血贡献最大。
