a School of Environment and Energy , South China University of Technology, Guangzhou Higher Education Mega Centre , Guangzhou , PR China.
b The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters, Ministry of Education , South China University of Technology, Guangzhou Higher Education Mega Centre , Guangzhou , PR China.
Crit Rev Biotechnol. 2018 Dec;38(8):1195-1208. doi: 10.1080/07388551.2018.1471038. Epub 2018 May 28.
Antimicrobial and antibiotics resistance caused by misuse or overuse of antibiotics exposure is a growing and significant threat to global public health. The spread and horizontal transfer of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) by the selective pressure of antibiotics in an aquatic environment is a major public health issue. To develop a better understanding of potential ecological risks die to antibiotics and ARGs, this study mainly summarizes research progress about: (i) the occurrence, concentration, fate, and potential ecological effects of antibiotics and ARGs in various aquatic environments, (ii) the threat, spread, and horizontal gene transfer (HGT) of ARGs, and (iii) the relationship between antibiotics, ARGs, and ARB. Finally, this review also proposes future research direction on antibiotics and ARGs.
抗生素的滥用和过度使用导致的抗微生物和抗生素耐药性，是对全球公共卫生的一个日益严重和重大的威胁。在水生环境中，抗生素的选择性压力会导致抗生素耐药细菌（ARB）和抗生素耐药基因（ARGs）的传播和水平转移，这是一个主要的公共卫生问题。为了更好地了解抗生素和 ARGs 可能带来的生态风险，本研究主要总结了以下方面的研究进展：（i）抗生素和 ARGs 在各种水生环境中的发生、浓度、归宿和潜在生态影响，（ii）ARGs 的威胁、传播和水平基因转移（HGT），以及（iii）抗生素、ARGs 和 ARB 之间的关系。最后，本综述还提出了抗生素和 ARGs 的未来研究方向。
