Albeshri Sultan, Alblaihess Abdulaziz, Niazy Abdurahman A, Ramalingam Sundar, Sundar Chalini, Alghamdi Hamdan S
Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Molecular and Cell Biology Laboratory and Department of Diagnostic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Kingdom of Saudi Arabia.
J Contemp Dent Pract. 2018 May 1;19(5):605-618.
Biomarkers are detected during bone formation and resorption associated with the dynamics of bone metabolism and are gaining importance as preferential indicators of bone healing in comparison with conventional methodologies. Current literature suggests that the usage of bone turnover markers for monitoring bone regeneration in association with biomaterials is limited.
To systematically review literature and evaluate whether bone-biomarkers can independently predict bone regeneration following implantation of various bone biomaterials.
An electronic search was conducted in PubMed (MEDLINE) database from 1980 to January 2017. The articles for systematic review were selected based on formulated inclusion and exclusion criteria Results: Upon database searching, 443 articles were retrieved and thoroughly reviewed based on the inclusion and exclusion criteria. In all, 41 studies were finally included for evaluation out of which 4 were clinical studies and the remaining 37 studies utilized animal models. On further evaluation, 12 studies reported the presence of biomarkers in association with cellular response during bone regeneration around bio-materials. Moreover, biomarkers related to enzyme activity and matrix protein derivatives were enhanced during bone-matrix deposition as reported in 14 studies. Inorganic skeletal matrix biomarkers indicative of bone mineralization showed positive expression in eight studies.
Several biomarkers appear to be useful for the assessment of bone regeneration around biomaterials. Although biomarkers are capable of independently predicting bone regeneration, lack of substantial evidence in the literature limits their true clinical utility.
Noninvasive and inexpensive methods of isolating and characterization of biomarkers from cellular and extracellular skeletal matrix during bone regeneration have proven value in evaluating success of bone biomaterials.
生物标志物在与骨代谢动态相关的骨形成和吸收过程中被检测到，与传统方法相比，作为骨愈合的优先指标正变得越来越重要。当前文献表明，骨转换标志物用于监测与生物材料相关的骨再生的用途有限。
系统回顾文献，评估骨生物标志物是否能独立预测各种骨生物材料植入后的骨再生情况。
在1980年至2017年1月期间对PubMed（MEDLINE）数据库进行电子检索。根据制定的纳入和排除标准选择用于系统评价的文章。结果：在数据库检索中，共检索到443篇文章，并根据纳入和排除标准进行了全面审查。最终纳入41项研究进行评估，其中4项为临床研究，其余37项研究使用动物模型。进一步评估发现，12项研究报告了生物标志物与生物材料周围骨再生过程中的细胞反应有关。此外，14项研究报告称，与酶活性和基质蛋白衍生物相关的生物标志物在骨基质沉积过程中有所增强。8项研究中，指示骨矿化的无机骨骼基质生物标志物呈阳性表达。
几种生物标志物似乎对评估生物材料周围的骨再生有用。尽管生物标志物能够独立预测骨再生，但文献中缺乏充分证据限制了它们的实际临床应用。
在骨再生过程中，从细胞和细胞外骨骼基质中分离和鉴定生物标志物的非侵入性且廉价的方法，在评估骨生物材料的成功方面已被证明具有价值。
