Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080, USA.
Adv Healthc Mater. 2018 Jul;7(13):e1701503. doi: 10.1002/adhm.201701503. Epub 2018 May 29.
The increase of antibiotic resistance in bacteria has become a major concern for successful diagnosis and treatment of infectious diseases. Over the past few decades, significant progress has been achieved on the development of nanotechnology-based medicines for combating multidrug resistance in microorganisms. Among this, silver nanoparticles (AgNPs) hold great promise in addressing this challenge due to their broad-spectrum and robust antimicrobial properties. This review illustrates the antibacterial mechanisms of silver nanoparticles and further elucidates how different structural factors including surface chemistry, size, and shape, impact their antibacterial activities, which are expected to promote the future development of more potent silver nanoparticle-based antibacterial agents.
细菌对抗生素耐药性的增加已成为成功诊断和治疗传染病的主要关注点。在过去几十年中，在开发基于纳米技术的药物以对抗微生物的多药耐药性方面取得了重大进展。在这其中，由于其广谱和强大的抗菌特性，银纳米粒子（AgNPs）在解决这一挑战方面具有巨大的潜力。本综述说明了银纳米粒子的抗菌机制，并进一步阐明了包括表面化学、尺寸和形状在内的不同结构因素如何影响其抗菌活性，这有望促进更有效的基于银纳米粒子的抗菌剂的未来发展。
